ArticleThe EMBO journal2005
G-protein gamma subunit 1 is required for sugar reception in Drosophila.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Hawkmoth Pheromone Transduction Involves G-Protein-Dependent Phospholipase Cβ Signaling.eNeuro · 2025Article
- Review
- Temperature and Sweet Taste Integration in Drosophila.Current biology : CB · 2020Article
- Membrane Proteins Mediating Reception and Transduction in Chemosensory Neurons in Mosquitoes.Frontiers in physiology · 2018Review
- Effects of age and nutritional state on the expression of gustatory receptors in the honeybee (Apis mellifera).PloS one · 2017Article
- Morphological and Transcriptomic Analysis of a Beetle Chemosensory System Reveals a Gnathal Olfactory Center.BMC biology · 2016Article
- A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis.BMC developmental biology · 2016Article
- Molecular neurobiology of Drosophila taste.Current opinion in neurobiology · 2015Review
- Molecular Cloning and Characterization of G Alpha Proteins from the Western Tarnished Plant Bug, Lygus hesperus.Insects · 2014Article
- Peripheral coding of taste.Neuron · 2014Review
- Neural mechanisms of alarm pheromone signaling.Molecules and cells · 2013Review
- Female behaviour drives expression and evolution of gustatory receptors in butterflies.PLoS genetics · 2013Article
- Gαo is required for L-canavanine detection in Drosophila.PloS one · 2013Article
- Sugar-regulated cation channel formed by an insect gustatory receptor.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The stimulatory Gα(s) protein is involved in olfactory signal transduction in Drosophila.PloS one · 2011Article
- Article
- C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.Nature neuroscience · 2010Article
- Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
- FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation.Development (Cambridge, England) · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though G-proteins have been implicated in the primary step of taste signal transduction, no direct demonstration has been done in insects. We show here that a G-protein gamma subunit, Ggamma1, is required for the signal transduction of sugar taste reception in Drosophila. The Ggamma1 gene is expressed mainly in one of the gustatory receptor neurons. Behavioral responses of the flies to sucrose were reduced by the targeted suppression of neural functions of Ggamma1-expressing cells using neural modulator genes such as the modified Shaker K+ channel (EKO), the tetanus toxin light chain or the shibire (shi(ts1)) gene. RNA interference targeting to the Ggamma1 gene reduced the amount of Ggamma1 mRNA and suppressed electrophysiological response of the sugar receptor neuron. We also demonstrated that responses to sugars were lowered in Ggamma1 null mutant, Ggamma1(N159). These results are consistent with the hypothesis that Ggamma1 participates in the signal transduction of sugar taste reception.
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