ArticleMolecular biology of the cell2005
Separate functions of gelsolin mediate sequential steps of collagen phagocytosis.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis.Cells · 2025Review
- The therapeutic potential of gelsolin in attenuating cytokine storm, ARDS, and ALI in severe COVID-19.Frontiers in pharmacology · 2024Review
- Spatial and chronological localization of septoclasts in the mouse Meckel's cartilage.Histochemistry and cell biology · 2022Article
- Gelsolin expression increases β1 -integrin affinity and L1210 cell adhesion.Cytoskeleton (Hoboken, N.J.) · 2013Article
- Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions.Molecular biology of the cell · 2013Article
- The role of CD38 in Fcγ receptor (FcγR)-mediated phagocytosis in murine macrophages.The Journal of biological chemistry · 2012Article
- Gelsolin and non-muscle myosin IIA interact to mediate calcium-regulated collagen phagocytosis.The Journal of biological chemistry · 2011Article
- The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape.BMC systems biology · 2010Article
- Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia).The Journal of biological chemistry · 2010Article
- Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A.Molecular biology of the cell · 2008Article
- Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2.American journal of physiology. Cell physiology · 2008Article
- The intriguing normal acute inflammatory response in mice lacking vimentin.Clinical and experimental immunology · 2007Article
- Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases.Pflugers Archiv : European journal of physiology · 2007Review
- Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions.Molecular biology of the cell · 2007Article
- Gravity: one of the driving forces for evolution.Protoplasma · 2006Review
- A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis.Molecular biology of the cell · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen phagocytosis is a critical mediator of extracellular matrix remodeling. Whereas the binding step of collagen phagocytosis is facilitated by Ca2+-dependent, gelsolin-mediated severing of actin filaments, the regulation of the collagen internalization step is not defined. We determined here whether phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] regulation of gelsolin is required for collagen internalization. In gelsolin null fibroblasts transfected with gelsolin severing mutants, actin severing and collagen binding were strongly impaired but internalization and actin monomer addition at collagen bead sites were much less affected. PI(4,5)P2 accumulated around collagen during internalization and was associated with gelsolin. Cell-permeable peptides mimicking the PI(4,5)P2 binding site of gelsolin blocked actin monomer addition, the association of gelsolin with actin at phagosomes, and collagen internalization but did not affect collagen binding. Collagen beads induced recruitment of type 1 gamma phosphatidylinositol phosphate kinase (PIPK1gamma661) to internalization sites. Dominant negative constructs and RNA interference demonstrated a requirement for catalytically active PIPK1gamma661 for collagen internalization. We conclude that separate functions of gelsolin mediate sequential stages of collagen phagocytosis: Ca2+-dependent actin severing facilitates collagen binding, whereas PI(4,5)P2-dependent regulation of gelsolin promotes the actin assembly required for internalization of collagen fibrils.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.