ArticleDevelopmental biology2005
Roles of cell-intrinsic and microenvironmental factors in photoreceptor cell differentiation.
Article in Developmental biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Development and postnatal neurogenesis in the retina: a comparison between altricial and precocial bird species.Neural regeneration research · 2021Article
- Automated Hypothesis Generation to Identify Signals Relevant in the Development of Mammalian Cell and Tissue Bioprocesses, With Validation in a Retinal Culture System.Frontiers in bioengineering and biotechnology · 2020Article
- Adult Stem Cells, Tools for Repairing the Retina.Current ophthalmology reports · 2019Article
- Early divergence of central and peripheral neural retina precursors during vertebrate eye development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Transcriptome profiling of developing photoreceptor subtypes reveals candidate genes involved in avian photoreceptor diversification.The Journal of comparative neurology · 2015Article
- A high content screening approach to identify molecules neuroprotective for photoreceptor cells.Advances in experimental medicine and biology · 2014Article
- The maturation of photoreceptors in the avian retina is stimulated by thyroid hormone.Neuroscience · 2011Article
- Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.The Journal of biological chemistry · 2010Article
- Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells.Journal of cellular physiology · 2010Article
- Cell transplantation strategies for retinal repair.Progress in brain research · 2009Review
- Have we achieved a unified model of photoreceptor cell fate specification in vertebrates?Brain research · 2008Review
- Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina.The Journal of comparative neurology · 2008Article
- Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells.Developmental biology · 2007Article
- Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin2 mutant glass onion and zebrafish cadherin4 morphants.Experimental eye research · 2007Article
- Neurogenesis in the fish retina.International review of cytology · 2007Review
- Challenges in the study of neuronal differentiation: a view from the embryonic eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2005Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Photoreceptor differentiation requires the coordinated expression of numerous genes. It is unknown whether those genes share common regulatory mechanisms or are independently regulated by distinct mechanisms. To distinguish between these scenarios, we have used in situ hybridization, RT-PCR, and real-time PCR to analyze the expression of visual pigments and other photoreceptor-specific genes during chick embryo retinal development in ovo, as well as in retinal cell cultures treated with molecules that regulate the expression of particular visual pigments. In ovo, onset of gene expression was asynchronous, becoming detectable at the time of photoreceptor generation (ED 5-8) for some photoreceptor genes, but only around the time of outer segment formation (ED 14-16) for others. Treatment of retinal cell cultures with activin, staurosporine, or CNTF selectively induced or down-regulated specific visual pigment genes, but many cognate rod- or cone-specific genes were not affected by the treatments. These results indicate that many photoreceptor genes are independently regulated during development, are consistent with the existence of at least two distinct stages of gene expression during photoreceptor differentiation, suggest that intrinsic, coordinated regulation of a cascade of gene expression triggered by a commitment to the photoreceptor fate is not a general mechanism of photoreceptor differentiation, and imply that using a single photoreceptor-specific "marker" as a proxy to identify photoreceptor cell fate is problematic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.