ArticleVirology journal2005
Strategically examining the full-genome of dengue virus type 3 in clinical isolates reveals its mutation spectra.
Article in Virology journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 57 citations in OpenAlex.
- Molecular Characterization and Phylogenetic Analysis of Dengue Fever Viruses in Three Outbreaks in Tanzania Between 2017 and 2019.PLoS neglected tropical diseases · 2023Article
- Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Application of Next-Generation Sequencing to Reveal How Evolutionary Dynamics of Viral Population Shape Dengue Epidemiology.Frontiers in microbiology · 2020Review
- Inter- and intra-host sequence diversity reveal the emergence of viral variants during an overwintering epidemic caused by dengue virus serotype 2 in southern Taiwan.PLoS neglected tropical diseases · 2018Article
- Fitness peaks of dengue virus populations.PloS one · 2018Article
- Dengue viruses in Papua New Guinea: evidence of endemicity and phylogenetic variation, including the evolution of new genetic lineages.Emerging microbes & infections · 2017Article
- Dengue and Zika viruses: lessons learned from the similarities between these Aedes mosquito-vectored arboviruses.Journal of microbiology (Seoul, Korea) · 2017Review
- Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes.PLoS genetics · 2016Article
- Genomic studies of envelope gene sequences from mosquito and human samples from Bangkok, Thailand.SpringerPlus · 2016Article
- Molecular characterization of DENV-3 circulating during the post-monsoon period of 2013-14 in Delhi, India.Virologica Sinica · 2015Article
- Nature and Extent of Genetic Diversity of Dengue Viruses Determined by 454 Pyrosequencing.PloS one · 2015Article
- Analysis of Dengue Virus Genetic Diversity during Human and Mosquito Infection Reveals Genetic Constraints.PLoS neglected tropical diseases · 2015Article
- Distribution of fitness in populations of dengue viruses.PloS one · 2014Article
- Genetic variation in the 3' untranslated region of dengue virus serotype 3 strains isolated from mosquitoes and humans in Brazil.Virology journal · 2013Article
- Comparison of full-length genomics sequences between dengue virus serotype 3, parental strain, and its derivatives, and B-cell epitopes prediction from envelope region.Bioinformation · 2013Article
- Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity.Journal of virology · 2012Article
- Quasispecies of dengue virus.Tropical medicine and health · 2011Article
- Dengue--quo tu et quo vadis?Viruses · 2011Review
- Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene.Journal of virology · 2011Article
- Antibody recognition of the dengue virus proteome and implications for development of vaccines.Clinical and vaccine immunology : CVI · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies presented the quasispecies spectrum of the envelope region of dengue virus type 3 (DENV-3) from either clinical specimens or field-caught mosquitoes. However, the extent of sequence variation among full genomic sequences of DENV within infected individuals remains largely unknown.
resultsInstead of arbitrarily choosing one genomic region in this study, the full genomic consensus sequences of six DENV-3 isolates were used to locate four genomic regions that had a higher potential of sequence heterogeneity at capsid-premembrane (C-prM), envelope (E), nonstructural protein 3 (NS3), and NS5. The extent of sequence heterogeneity revealed by clonal sequencing was genomic region-dependent, whereas the NS3 and NS5 had lower sequence heterogeneity than C-prM and E. Interestingly, the Phylogenetic Analysis by Maximum Likelihood program (PAML) analysis supported that the domain III of E region, the most heterogeneous region analyzed, was under the influence of positive selection.
conclusionThis study confirmed previous reports that the most heterogeneous region of the dengue viral genome resided at the envelope region, of which the domain III was under positive selection pressure. Further studies will need to address the influence of these mutations on the overall fitness in different hosts (i.e., mosquito and human) during dengue viral transmission.
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