ArticleBMC cell biology2005
Crosstalk between the actin cytoskeleton and Ran-mediated nuclear transport.
Article in BMC cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Pitstop-2 and its novel derivative RVD-127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases.Bioengineering & translational medicine · 2023Article
- WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation.Molecules and cells · 2020Article
- Profilin: many facets of a small protein.Biophysical reviews · 2020Review
- Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis.Nature communications · 2019Article
- Importins α and β signaling mediates endothelial cell inflammation and barrier disruption.Cellular signalling · 2018Article
- Disruption of Microtubules Post-Virus Entry Enhances Adeno-Associated Virus Vector Transduction.Human gene therapy · 2016Article
- RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes.Nucleic acids research · 2013Article
- Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila.Frontiers in cellular and infection microbiology · 2012Article
- The nuclear pore complex: bridging nuclear transport and gene regulation.Nature reviews. Molecular cell biology · 2010Review
- Actin complexes in the cell nucleus: new stones in an old field.Histochemistry and cell biology · 2010Review
- Actin-depolymerizing factor2-mediated actin dynamics are essential for root-knot nematode infection of Arabidopsis.The Plant cell · 2009Article
- Large-scale selective sweep among Segregation Distorter chromosomes in African populations of Drosophila melanogaster.PLoS genetics · 2009Article
- A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila.Genetics · 2009Article
- Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy.Molecular vision · 2009Article
- ACTIN DEPOLYMERIZING FACTOR9 controls development and gene expression in Arabidopsis.Plant molecular biology · 2008Article
- Overexpression of RAN1 in rice and Arabidopsis alters primordial meristem, mitotic progress, and sensitivity to auxin.Plant physiology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransport of macromolecules into and out of the nucleus is a highly regulated process. The RanGTP/RanGDP gradient controls the trafficking of molecules exceeding the diffusion limit of the nuclear pore across the nuclear envelope.
resultsWe found genetic interaction between genes establishing the Ran gradient, nuclear transport factor 2 (ntf-2), Ran GTPase activating protein (Sd), and the gene encoding Drosophila Profilin, chickadee (chic). The severe eye phenotype caused by reduction of NTF2 is suppressed by loss of function mutations in chic and gain of function mutations in Sd (RanGAP). We show that in chic mutants, as in Sd-RanGAP, nuclear export is impaired.
conclusionOur data suggest that Profilin and the organization of the actin cytoskeleton play an important role in nuclear trafficking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.