ReviewClinical and experimental pharmacology & physiology2005
Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle.
Review in Clinical and experimental pharmacology & physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 98 citations in OpenAlex.
- Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone.American journal of physiology. Heart and circulatory physiology · 2009Trial
- Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress.Stem cell research & therapy · 2022Article
- Hypoxic Conditions Promote Rhythmic Contractile Oscillations Mediated by Voltage-Gated Sodium Channels Activation in Human Arteries.International journal of molecular sciences · 2021Article
- Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy.Frontiers in pharmacology · 2021Review
- Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.Pharmacological reviews · 2016Review
- TRPC6 is required for hypoxia-induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells.Molecular medicine reports · 2016Article
- Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function.Progress in molecular biology and translational science · 2015Review
- Vascular TRP channels: performing under pressure and going with the flow.Physiology (Bethesda, Md.) · 2014Review
- Bone morphogenetic protein 2 decreases TRPC expression, store-operated Ca(2+) entry, and basal [Ca(2+)]i in rat distal pulmonary arterial smooth muscle cells.American journal of physiology. Cell physiology · 2013Article
- Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Role of TRPM7 channels in hyperglycemia-mediated injury of vascular endothelial cells.PloS one · 2013Article
- Regulation of rat intrapulmonary arterial tone by arachidonic acid and prostaglandin E2 during hypoxia.PloS one · 2013Article
- Contribution and regulation of TRPC channels in store-operated Ca2+ entry.Current topics in membranes · 2013Review
- Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Canonical transient receptor potential channels in diabetes.Experimental biology and medicine (Maywood, N.J.) · 2012Review
- Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids.PloS one · 2012Article
- Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels.The Journal of pharmacology and experimental therapeutics · 2011Article
- Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling.Comprehensive Physiology · 2011Review
- Calcium oscillations.Cold Spring Harbor perspectives in biology · 2011Review
- A mathematical model of the myogenic response to systolic pressure in the afferent arteriole.American journal of physiology. Renal physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
1. The influx of Ca2+, Mg2+ and Na+ and the efflux of K+ have central importance for the function and survival of vascular smooth muscle cells, but progress in understanding the influx/efflux pathways has been restricted by a lack of identification of the genes underlying many of the non-voltage-gated cationic channels. 2. The present review highlights evidence suggesting the genes are mammalian homologues of the Transient Receptor Potential (TRP) gene of the fruit-fly Drosophila. The weight of evidence supports roles for TRPC1, TRPP2/1 and TRPC6, but recent studies point also to TRPC3, TRPC4/5, TRPV2, TRPM4 and TRPM7. 3. Activity of these TRP channels is suggested to modulate contraction and sense changes in intracellular Ca2+ storage, G-protein-coupled receptor activation and osmotic stress. Roles in relation to myogenic tone, actions of vasoconstrictors substances, Mg2+ homeostasis and the vascular injury response are suggested. 4. Knowledge that TRP channels are relevant to vascular smooth muscle cells in both their contractile and proliferative phenotypes should pave the way for a better understanding of vascular biology and provide the basis for the discovery of a new set of therapeutic agents targeted to vascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.