ArticleBritish journal of clinical pharmacology2005
Potential for drug interactions involving cytochrome P450 in patients attending palliative day care centres: a multicentre audit.
Article in British journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 24 citations in OpenAlex.
- The Burden of Polypharmacy in Patients Near the End of Life.Journal of pain and symptom management · 2016 · on this mapObservational
- Current and Emerging Options in the Management of EGFR Mutation-Positive Non-Small-Cell Lung Cancer: Considerations in the Elderly.Drugs & aging · 2015Review
- The treatment of metastatic non-small cell lung cancer in the elderly: an evidence-based approach.Frontiers in oncology · 2014Review
- Prevalence of drug interactions in hospital healthcare.International journal of clinical pharmacy · 2012Review
- Drug interactions in dying patients: a retrospective analysis of hospice inpatients in Germany.Drug safety · 2012Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the potential for drug interactions involving cytochrome P450 (CYP) in patients receiving palliative day care.
methodsDrugs used by patients attending four specialist palliative day care centres were reviewed to identify combinations that could result in a pharmacokinetic interaction via any of the five main human forms of CYP.
resultsOf 160 patients, 145 (91%) were prescribed at least one drug that was a substrate, inhibitor or inducer of one of the five main CYP isoforms. Twenty-four drug combinations, involving 34 patients, could have given rise to a clinically important interaction.
conclusionsPrescribers should be aware that in this group of patients, one in five are at risk of a clinically important CYP-mediated drug interaction.
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