ArticleProceedings of the National Academy of Sciences of the United States of America2005
Clusters of mutations from transient hypermutability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine: adenine pair triggered by MUTYH.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025Article
- No evidence for widespread positive selection on double substitutions within codons in primates and yeasts.Frontiers in genetics · 2022Article
- A Comprehensive View of Translesion Synthesis in Escherichia coli.Microbiology and molecular biology reviews : MMBR · 2020Review
- Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways.Nature communications · 2020Article
- Postzygotic Somatic Mutations in the Human Brain Expand the Threshold-Liability Model of Schizophrenia.Frontiers in psychiatry · 2020Review
- Crossing fitness valleys via double substitutions within codons.BMC biology · 2019Article
- What is mutation? A chapter in the series: How microbes "jeopardize" the modern synthesis.PLoS genetics · 2019Review
- Genome Plasticity ofInfection and immunity · 2018Article
- Real-time dynamics of mutagenesis reveal the chronology of DNA repair and damage tolerance responses in single cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Synthetic biology, genome mining, and combinatorial biosynthesis of NRPS-derived antibiotics: a perspective.Journal of industrial microbiology & biotechnology · 2018Article
- Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.Annual review of cancer biology · 2017Article
- Population Heterogeneity in Mutation Rate Increases the Frequency of Higher-Order Mutants and Reduces Long-Term Mutational Load.Molecular biology and evolution · 2017Article
- Bioinformatics and Drug Discovery.Current topics in medicinal chemistry · 2017Review
- Evolutionary switches between two serine codon sets are driven by selection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes.PLoS genetics · 2015Article
- DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA.PLoS genetics · 2015Article
- Error-prone polymerase activity causes multinucleotide mutations in humans.Genome research · 2014Article
- Correlation between mutation rate and genome size in riboviruses: mutation rate of bacteriophage Qβ.Genetics · 2013Article
- Evaluating evolutionary models of stress-induced mutagenesis in bacteria.Nature reviews. Genetics · 2013Review
- Generators of phenotypic diversity in the evolution of pathogenic microorganisms.PLoS pathogens · 2013Article
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4 authors.
Funding
Abstract
Collections of mutants usually contain more mutants bearing multiple mutations than expected from the mutant frequency and a random distribution of mutations. This excess is seen in a variety of organisms and also after DNA synthesis in vitro. The excess is unlikely to originate in mutator mutants but rather from transient hypermutability resulting from a perturbation of one of the many transactions that maintain genetic fidelity. The multiple mutations are sometimes clustered and sometimes randomly distributed. We model some spectra as populations comprising a majority with a low mutation frequency and a minority with a high mutation frequency. In the case of mutants produced in vitro by a bacteriophage RB69 mutator DNA polymerase, mutants with two mutations are in approximately 10-fold excess and mutants with three mutations are in even greater excess. However, phenotypically undetectable mutations seen only as hitchhikers with detectable mutations are approximately 5-fold more frequent than mutants bearing detectable mutations, indicating that they arose in a subpopulation with a higher mutation frequency. Excess multiple mutations may contribute critically to carcinogenesis and to adaptive mutation, including the adaptations of pathogens as they move from host to host. In the case of the rapidly mutating riboviruses, the viral population appears to be composed of a majority with a mutation frequency substantially lower than the average and a minority with a huge mutational load.
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