ArticleAmerican journal of physiology. Endocrinology and metabolism2006
Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression.
Article in American journal of physiology. Endocrinology and metabolism, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00108615. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
Who cites it
42 citing papers in PubMed, 115 citations in OpenAlex.
- Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW.Diabetes care · 2014Trial
- Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans.Arteriosclerosis, thrombosis, and vascular biology · 2009Trial
- Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial.Diabetologia · 2008Trial
- Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines.American journal of physiology. Endocrinology and metabolism · 2008Trial
- Role of systemic and epicardial adipose tissue in cardiometabolic disease.Nature reviews. Cardiology · 2026Review
- Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023Review
- Translational control of murine adiponectin expression by an upstream open reading frame element.RNA biology · 2023Article
- Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC.International journal of molecular sciences · 2021Review
- Autologous fat transplants to deliver glitazone and adiponectin for vasculoprotection.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids.European journal of nutrition · 2017Article
- The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans.Frontiers in endocrinology · 2017Article
- Increased Circulating Adiponectin in Response to Thiazolidinediones: Investigating the Role of Bone Marrow Adipose Tissue.Frontiers in endocrinology · 2016Article
- Adiponectin serum level in chronic hepatitis C infection and therapeutic profile.World journal of hepatology · 2015Review
- Assembly of adiponectin oligomers.Reviews in endocrine & metabolic disorders · 2014Review
- Synergistic anti-inflammatory effect: simvastatin and pioglitazone reduce inflammatory markers of plasma and epicardial adipose tissue of coronary patients with metabolic syndrome.Diabetology & metabolic syndrome · 2014Article
- Article
- Vanadyl acetylacetonate upregulates PPARγ and adiponectin expression in differentiated rat adipocytes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-γ both In Vitro and In Vivo in Mice Fed a High-Fat Diet.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Vascular biology of metabolic syndrome.Journal of vascular surgery · 2011Review
- Role of redox environment on the oligomerization of higher molecular weight adiponectin.BMC biochemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Plasma levels of adiponectin are lower in obese and insulin-resistant subjects compared with lean and insulin-sensitive ones. Thiazolidinediones increase plasma adiponectin levels in diabetic subjects, although the mechanism of this increased plasma adiponectin has not been well studied. In the present study, we compared the plasma levels and adipose tissue expression of adiponectin in subjects with normal (NGT) and impaired glucose tolerance (IGT) and also studied the effects of metformin and pioglitazone on plasma and adipose tissue mRNA level of adiponectin in IGT subjects. IGT subjects had lower plasma adiponectin levels compared with NGT subjects, and similarly IGT subjects had lower adiponectin mRNA levels. In contrast, the increased plasma levels of adiponectin in response to pioglitazone were not associated with increased adiponectin expression in adipose tissue. Metformin did not cause any change in plasma or expression levels of adiponectin. Other adipokines were examined, and both pioglitazone and metformin decreased plasma levels of resistin in IGT subjects, and pioglitazone (but not metformin) decreased plasma levels of leptin. These data suggest that pioglitazone increases plasma adiponectin levels by posttranscriptional regulation in contrast to transcriptional regulation of adiponectin in relation to insulin sensitivity in NGT vs. IGT subjects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.