ReviewPaediatric drugs2005
Hypersensitivity pneumonitis in children: clinical features, diagnosis, and treatment.
Review in Paediatric drugs, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Miliary Opacities Beyond Miliary Tuberculosis in an Adolescent Boy: Lessons Learned.Pediatric pulmonology · 2026Article
- The Challenging Diagnosis of Interstitial Lung Disease in Children-One Case Report and Literature Review.Journal of clinical medicine · 2022Article
- Interstitial lung disease in infancy and early childhood: a clinicopathological primer.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Pediatric hypersensitivity pneumonitis: literature update and proposal of a diagnostic algorithm.Italian journal of pediatrics · 2022Review
- Recurrent hypoxemia: When crackles crack the case.Pediatric pulmonology · 2021Article
- Clinical Features of Hypersensitivity Pneumonitis in Children: A Single Center Study.Frontiers in pediatrics · 2021Article
- [Bird fancier's disease in a child: about a rare and unusual case].The Pan African medical journal · 2020Article
- A Rare Pediatric Case of Severe Bird Fancier's Lung Presented with Viral Pneumonitis-Like Picture.Children (Basel, Switzerland) · 2018Article
- Mimicking hypersensitivity pneumonitis as an uncommon initial presentation of chronic granulomatous disease in children.Orphanet journal of rare diseases · 2017Article
- An unusual radiologic manifestation of hypersensitivity pneumonia.Radiology case reports · 2017Article
- Interstitial Lung Disease in Childhood: Clinical and Genetic Aspects.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2015Review
- Application of clinico-radiologic-pathologic diagnosis of diffuse parenchymal lung diseases in children in China.PloS one · 2015Article
- Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence.Environmental health perspectives · 2011Review
- Interstitial lung diseases in children.Orphanet journal of rare diseases · 2010Review
- Interstitial Lung Disease in Children Older Than 2 Years.Pediatric allergy, immunology, and pulmonology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is a form of immune-mediated inflammatory lung disease involving the distal portions of the lungs associated with intense or repeated exposure to a variety of finely dispersed environmental antigens. Although once believed to be a disease of adults because of its frequent association with the occupational setting, HP exists in the pediatric population and often goes unrecognized. Childhood HP is often associated with exposure to antigens in the home environment as well as with certain hobbies. Patients present in any one of the three disease stages: acute, subacute, and chronic, all with unique clinical presentations. Histopathologic findings depend on the disease stage at the time of evaluation. The immuno-pathogenesis is complex, but immune-complex (type III hypersensitivity) and cell-mediated (type IV hypersensitivity) immune responses appear to be the primary immune mechanisms involved in the pathogenesis of HP. Diagnosis can be very challenging. Although no single diagnostic or clinical laboratory test is available to diagnose HP, the most significant diagnostic tool is a detailed environmental exposure history. Avoidance of the inciting antigen is the most important form of treatment. Acute HP is responsive to antigen removal alone. However, a short course of prednisone for 2-3 weeks can be useful in patients with severe attacks. Subacute and chronic HP may require higher doses of corticosteroids for a longer duration (i.e. months); however, the long-term efficacy of using corticosteroids is still not well defined. As with most hypersensitivity diseases, early diagnosis provides the best prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.