ArticleOncogene2005
A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Review
- Detection of alternative lengthening of telomeres mechanism on tumor sections.Molecular biomedicine · 2021Article
- Review
- Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres.Genes & development · 2020Article
- Protein Synthesis by Day 16 Bovine Conceptuses during the Time of Maternal Recognition of Pregnancy.International journal of molecular sciences · 2020Article
- The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas.Acta neuropathologica communications · 2019Article
- Senescence-associated β-galactosidase staining in fish cell lines and primary cultures from several tissues and species, including rainbow trout coelomic fluid and milt.In vitro cellular & developmental biology. Animal · 2015Article
- Telomerase-dependent and independent telomere maintenance and its clinical implications in medullary thyroid carcinoma.The Journal of clinical endocrinology and metabolism · 2014Article
- Dynamic length changes of telomeres and their nuclear organization in chronic myeloid leukemia.Cancers · 2013Article
- ZNF365 promotes stability of fragile sites and telomeres.Cancer discovery · 2013Article
- Presence of alternative lengthening of telomeres associated circular extrachromosome telomere repeats in primary leukemia cells of chronic myeloid leukemia.Journal of hematology & oncology · 2013Article
- Detection of alternative lengthening of telomeres by telomere quantitative PCR.Nucleic acids research · 2013Article
- Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Molecular and cellular biology · 2012Article
- Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2012Article
- Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.The American journal of pathology · 2011Article
- HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.PloS one · 2011Article
- Telomeric recombination induced by dysfunctional telomeres.Molecular biology of the cell · 2011Article
- Molecular and cellular evidence for the alternative lengthening of telomeres (ALT) mechanism in chicken.Cytogenetic and genome research · 2011Article
- CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In human somatic cells proliferation results in telomere shortening due to the end replication problem and the absence of adequate levels of telomerase activity. The progressive loss of telomeric DNA has been associated with replicative senescence. Maintenance of telomere structure and function is, therefore, an essential requisite for cells that proliferate indefinitely. Human cells that have acquired the immortal phenotype mostly rely on telomerase to compensate for telomere shortening with cell division. However, a certain percentage of immortalized cell lines and human tumors maintain their telomeres by Alternative Lengthening of Telomeres (ALT), a mechanism not fully understood but apparently based on homologous recombination. Here, we report the isolation of an immortal human cell line that is derived from an ALT cell line but maintains telomeres in the absence of key features of ALT and of telomerase. The properties of these cells suggest that the identification of ALT cells may not be reliably based on known ALT markers. This finding is of relevance for discriminating between the mortal and immortal phenotype among telomerase-negative cells in vitro and in vivo, particularly in regard to the development of pharmacological approaches for cancer treatment based on telomerase inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.