ArticleOncogene2006
E2F1 stability is regulated by a novel-PKC/p38beta MAP kinase signaling pathway during keratinocyte differentiation.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Role of Kindlin-2 in Cutaneous Squamous Carcinoma Cell Migration and Proliferation: Implications for Tumour Progression.International journal of molecular sciences · 2025Article
- Calcineurin-mediated dephosphorylation stabilizes E2F1 protein by suppressing binding of the FBXW7 ubiquitin ligase subunit.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network.Cancer research communications · 2024Article
- Article
- Scaffolding proteins in the development and maintenance of the epidermal permeability barrier.Tissue barriers · 2017Review
- CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes.Oncotarget · 2017Article
- Article
- FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance.Oncogene · 2013Article
- Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer.Molecular & cellular proteomics : MCP · 2012Article
- The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.Nucleus (Austin, Tex.) · 2012Article
- Article
- Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation.BMC genomics · 2010Article
- Ceramide synthase 1 is regulated by proteasomal mediated turnover.Biochimica et biophysica acta · 2009Article
- Phosphorylation by p38 MAP kinase is required for E2F1 degradation and keratinocyte differentiation.Oncogene · 2009Article
- Human papillomaviruses, cervical cancer and cell polarity.Oncogene · 2008Review
- Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation.Oncogene · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E2F transcription factors regulate proliferation, differentiation, DNA repair and apoptosis. Tight E2F regulation is crucial for epidermal formation and regeneration. However, virtually nothing is known about the molecular events modulating E2F during epidermal keratinocyte differentiation. Elucidation of these events is essential to understand epidermal morphogenesis, transformation and repair. Here we show that, in differentiating keratinocytes, Ca(2+)-induced protein kinase C (PKC) activation downregulates E2F1 protein levels. Further, we have identified PKC delta and eta as those isoforms specifically involved in induction of E2F1 proteasomal degradation. We also demonstrate that E2F1 downregulation by novel PKC isozymes requires activation of p38beta mitogen-activated protein kinase (MAPK). This is the first example of regulation in the E2F transcription factor family by activation of PKC and MAPK in the context of biologically significant differentiation stimuli in epithelia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.