ArticleProceedings of the National Academy of Sciences of the United States of America2005
Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Cell-cycle-specific lesion evolution rather than inhibition of double-strand-break repair underpins cisplatin radiosensitization.Molecular oncology · 2026Article
- Emerging role of non-coding RNAs in resistance to platinum-based anti-cancer agents in lung cancer.Frontiers in pharmacology · 2023Review
- Is Autophagy Always a Barrier to Cisplatin Therapy?Biomolecules · 2022Review
- Cisplatin fastens chromatin irreversibly even at a high chloride concentration.Nucleic acids research · 2021Article
- The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents.Frontiers in pharmacology · 2020Review
- Nucleotide Excision Repair and Impact of Site-Specific 5',8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes.Biochemistry · 2019Article
- Chromatin Regulates Genome Targeting with Cisplatin.Angewandte Chemie (International ed. in English) · 2017Article
- Effect of the Spiroiminodihydantoin Lesion on Nucleosome Stability and Positioning.Biochemistry · 2016Article
- Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage.DNA repair · 2015Review
- Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function.American journal of physiology. Renal physiology · 2013Article
- Visualizing inhibition of nucleosome mobility and transcription by cisplatin-DNA interstrand crosslinks in live mammalian cells.Cancer research · 2013Article
- Photochemical internalization-mediated delivery of chemotherapeutic agents in human breast tumor cell lines.Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer · 2012Article
- Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation.Nucleic acids research · 2011Article
- Consequences of cisplatin binding on nucleosome structure and dynamics.Chemistry & biology · 2010Article
- Perturbations in nucleosome structure from heavy metal association.Nucleic acids research · 2010Article
- Rapid cross-linking of an RNA internal loop by the anticancer drug cisplatin.Journal of the American Chemical Society · 2009Article
- DNA sequence-directed organization of chromatin: structure-based computational analysis of nucleosome-binding sequences.Biophysical journal · 2009Article
- Inhibition of transcription by platinum antitumor compounds.Metallomics : integrated biometal science · 2009Review
- A 1,2-d(GpG) cisplatin intrastrand cross-link influences the rotational and translational setting of DNA in nucleosomes.Journal of the American Chemical Society · 2008Article
- Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis.Pharmacogenetics and genomics · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We constructed two site-specifically modified nucleosomes containing an intrastrand cis-{Pt(NH3)2}2+ 1,3-d(GpTpG) cross-link, similar to one formed by the anticancer drugs carboplatin and cisplatin on DNA, and investigated their structures by hydroxyl radical footprinting and exonuclease III digestion. Hydroxyl radical footprinting demonstrated that the presence of the platinum cross-link selects out a specific rotational setting of DNA on the histone octamer core in each of two reconstituted nucleosomes in which the platinum positions differ by half a DNA helical turn. The {Pt(NH3)2}2+ cross-link is situated in a structurally similar location, with the undamaged strand projecting outward, forcing the DNA to adopt opposite rotational settings in its wrapping around the histone octamer in the two nucleosomes. Enzymatic digestion by exonuclease III of the nucleosome substrates revealed that the platinum cross-link affects the translational positioning of the DNA, forcing it into an asymmetric arrangement with respect to the core histone proteins. We suggest that these phasing phenomena may be central to the recognition and processing of platinum-DNA adducts in cancer cells treated with these drugs and possibly may be common to other DNA damaging events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.