ArticleProceedings of the National Academy of Sciences of the United States of America2005
A funneled energy landscape for cytochrome c directly predicts the sequential folding route inferred from hydrogen exchange experiments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- From static structures to dynamic energy landscapes: the latest revolution in molecular biology.Current opinion in structural biology · 2026Review
- Reassessing the exon-foldon correspondence using frustration analysis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- On the role of native contact cooperativity in protein folding.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genetically Encoded Fluorescent Probe for Detection of Heme-Induced Conformational Changes in Cytochrome c.Biosensors · 2023Article
- Exploring the folding energy landscapes of heme proteins using a hybrid AWSEM-heme model.Journal of biological physics · 2022Article
- Dramatic Shape Changes Occur as CytochromeThe journal of physical chemistry. B · 2020Article
- Simulations Reveal Multiple Intermediates in the Unzipping Mechanism of Neuronal SNARE Complex.Biophysical journal · 2018Article
- Molecular origin of the weak susceptibility of kinesin velocity to loads and its relation to the collective behavior of kinesins.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The case for defined protein folding pathways.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Protein Folding-How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry.Annual review of biophysics · 2016Review
- SMOG 2: A Versatile Software Package for Generating Structure-Based Models.PLoS computational biology · 2016Article
- The nature of protein folding pathways.Proceedings of the National Academy of Sciences of the United States of America · 2014Review
- Frustration in biomolecules.Quarterly reviews of biophysics · 2014Review
- Learning To Fold Proteins Using Energy Landscape Theory.Israel journal of chemistry · 2014Article
- Structural transformations of cytochrome c upon interaction with cardiolipin.Chemistry and physics of lipids · 2014Review
- Becoming a peroxidase: cardiolipin-induced unfolding of cytochrome c.The journal of physical chemistry. B · 2013Article
- Mapping polymerization and allostery of hemoglobin S using point mutations.The journal of physical chemistry. B · 2013Article
- Investigations of the low-frequency spectral density of cytochrome c upon equilibrium unfolding.The journal of physical chemistry. B · 2013Article
- Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Impact of mutations on the allosteric conformational equilibrium.Journal of molecular biology · 2013Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Proteins fold through a variety of mechanisms. For a given protein, folding routes largely depend on the protein's stability and its native-state geometry, because the landscape is funneled. These ideas are corroborated for cytochrome c by using a coarse-grained topology-based model with a perfect funnel landscape that includes explicit modeling of the heme. The results show the importance of the heme as a nucleation site and explain the observed hydrogen exchange patterns of cytochrome c within the context of energy landscape theory.
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