ArticleEMBO reports2005
Plant and animal homeodomains use convergent mechanisms for intercellular transfer.
Article in EMBO reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- Role of PI(4,5)P2 and Cholesterol in Unconventional Protein Secretion.Advances in experimental medicine and biology · 2023Article
- Unconventional Secretion, Gate to Homeoprotein Intercellular Transfer.Frontiers in cell and developmental biology · 2022Review
- Shuttling Homeoproteins and Their Biological Significance.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Homeoprotein transduction in neurodevelopment and physiopathology.Science advances · 2020Review
- Review
- Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.PloS one · 2015Article
- Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking.Plant signaling & behavior · 2014Article
- Characterization of a novel cell penetrating peptide derived from human Oct4.Cell regeneration (London, England) · 2014Article
- Signaling with homeoprotein transcription factors in development and throughout adulthood.Current genomics · 2013Article
- Investigation of homeodomain membrane translocation properties: insights from the structure determination of engrailed-2 homeodomain in aqueous and membrane-mimetic environments.Biophysical journal · 2013Article
- Uniform categorization of biocommunication in bacteria, fungi and plants.World journal of biological chemistry · 2010Article
- Both the conserved GRAS domain and nuclear localization are required for SHORT-ROOT movement.The Plant journal : for cell and molecular biology · 2009Article
- The physiological basis of intracrine stem cell regulation.American journal of physiology. Heart and circulatory physiology · 2008Review
- Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP.Neural development · 2008Article
- Plant communication from biosemiotic perspective: differences in abiotic and biotic signal perception determine content arrangement of response behavior. Context determines meaning of meta-, inter- and intraorganismic plant signaling.Plant signaling & behavior · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeoproteins are defined by the structure of their DNA-binding domain, the homeodomain. Intercellular transfer of homeoprotein was observed ex vivo between animal cells and in vivo in higher plants. In the latter case, transfer is through intercytoplasmic channels that connect plant cells, but these do not exist in animals. Here, we show that the homeodomain of KNOTTED1, a maize homeoprotein, is transferred between animal cells and that a mutation in the homeodomain blocking the intercellular transfer of KNOTTED1 in plants also inhibits the transfer of the KNOTTED1 homeodomain in animal cells. This mutation decreases nuclear addressing, and its effect on nuclear import and intercellular transfer is reverted by the addition of an ectopic nuclear localization signal. We propose that, despite evolutionary distance and the differences in multicellular organization, similar mechanisms are at work for intercellular transfer of homeoprotein in plants and animals. Furthermore, our results suggest that, at least in animals, homeodomain secretion requires passage through the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.