ReviewProceedings of the American Thoracic Society2005
Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease.
Review in Proceedings of the American Thoracic Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Effectiveness of supplementation with quercetin-type flavonols for treatment of viral lower respiratory tract infections: Systematic review and meta-analysis of preclinical studies.Phytotherapy research : PTR · 2021Pooled it
- Serum Allergen-Specific Immunoglobulin E in Cats with Inflammatory Bronchial Disease.Animals : an open access journal from MDPI · 2023Article
- In Vitro Characteristics of Canine Primary Tracheal Epithelial Cells Maintained at an Air-Liquid Interface Compared to In Vivo Morphology.International journal of molecular sciences · 2023Article
- Article
- Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection.American journal of respiratory cell and molecular biology · 2022Article
- Non-Pharmaceutical Techniques for Obstructive Airway Clearance Focusing on the Role of Oscillating Positive Expiratory Pressure (OPEP): A Narrative Review.Pulmonary therapy · 2022Review
- Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects.Scientific reports · 2020Article
- Quantitative single-cell interactomes in normal and virus-infected mouse lungs.Disease models & mechanisms · 2020Article
- Clinical issues of mucus accumulation in COPD.International journal of chronic obstructive pulmonary disease · 2014Review
- Article
- Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge.Disease models & mechanisms · 2013Article
- Chronic bronchitis and chronic obstructive pulmonary disease.American journal of respiratory and critical care medicine · 2013Review
- PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study.Cough (London, England) · 2012Article
- The influence of virus infections on the course of COPD.European journal of microbiology & immunology · 2012Review
- Monitoring in vivo changes in lung microstructure with ³He MRI in Sendai virus-infected mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Article
- Responses of airway epithelium to environmental injury: role in the induction phase of childhood asthma.Journal of allergy · 2011Article
- Lower risk of lung cancer after multiple pneumonia diagnoses.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010Article
- Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice.Respiratory research · 2010Article
- Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the high clinical impact of established and emerging respiratory viruses, some critical aspects of the host response to these pathogens still need to be defined. In that context, we aimed at two major issues: first, what are the innate immune mechanisms that control common respiratory viral infections; and second, whether these mechanisms also cause long-term airway disease. Using a mouse model of viral bronchiolitis, we found that antiviral defense depends at least in part on a network of mucosal epithelial cells and macrophages specially programmed for immune-response gene expression. When this network is compromised, the host is highly susceptible to infection, but network components can be engineered to provide increased resistance to infection. Similar alterations appear in asthma and chronic bronchitis/chronic obstructive pulmonary disease, suggesting that evolving attempts to improve antiviral defense may also lead to inflammatory airway disease. Indeed, in genetically susceptible mice, respiratory paramyxoviruses cause a "hit and run" phenomenon that is manifested by the development of a permanent airway disease phenotype long after the infection has cleared. The phenotype can be segregated into individual traits to achieve more precise definition of just how viruses reprogram host behavior. Identifying specific components of the mucosal immune system that manifest an aberrant antiviral response may thereby allow for adjusting this response to improve acute and chronic outcomes after viral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.