ArticleInfection and immunity2005
Identification of group A Streptococcus antigenic determinants upregulated in vivo.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Immunoprotective Efficacy of SixFrontiers in microbiology · 2016Article
- Identification of Enterococcus faecalis antigens specifically expressed in vivo.Restorative dentistry & endodontics · 2015Article
- Identification of Salmonella enterica serovar Pullorum antigenic determinants expressed in vivo.Infection and immunity · 2013Article
- Identification and real-time expression analysis of selected Toxoplasma gondii in-vivo induced antigens recognized by IgG and IgM in sera of acute toxoplasmosis patients.BMC infectious diseases · 2013Article
- Identification of in vivo-induced antigens including an RTX family exoprotein required for uropathogenic Escherichia coli virulence.Infection and immunity · 2011Article
- Development of a single-step subtraction method for eukaryotic 18S and 28S ribonucleic acids.Journal of biomedicine & biotechnology · 2011Article
- Immunoproteomic analysis of human serological antibody responses to vaccination with whole-cell pertussis vaccine (WCV).PloS one · 2010Article
- Identification of Leishmania proteins preferentially released in infected cells using change mediated antigen technology (CMAT).PLoS neglected tropical diseases · 2010Article
- Use of in vivo-induced antigen technology (IVIAT) for the identification of Streptococcus suis serotype 2 in vivo-induced bacterial protein antigens.BMC microbiology · 2009Article
- Article
- Role for sagA and siaA in quorum sensing and iron regulation in Streptococcus pyogenes.Infection and immunity · 2007Article
- Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides.Infection and immunity · 2006Article
- Analysis of the transcriptome of group A Streptococcus in mouse soft tissue infection.The American journal of pathology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Group A Streptococcus (GAS) causes a range of diseases in humans, from mild noninvasive infections to severe invasive infections. The molecular basis for the varying severity of disease remains unclear. We identified genes expressed during invasive disease using in vivo-induced antigen technology (IVIAT), applied for the first time in a gram-positive organism. Convalescent-phase sera from patients with invasive disease were pooled, adsorbed against antigens derived from in vitro-grown GAS, and used to screen a GAS genomic expression library. A murine model of invasive GAS disease was included as an additional source of sera for screening. Sequencing DNA inserts from clones reactive with both human and mouse sera indicated 16 open reading frames with homology to genes involved in metabolic activity to genes of unknown function. Of these, seven genes were assessed for their differential expression by quantitative real-time PCR both in vivo, utilizing a murine model of invasive GAS disease, and in vitro at different time points of growth. Three gene products-a putative penicillin-binding protein 1A, a putative lipoprotein, and a conserved hypothetical protein homologous to a putative translation initiation inhibitor in Vibrio vulnificus-were upregulated in vivo, suggesting that these genes play a role during invasive disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.