ArticleInfection and immunity2005
Bordetella pertussis risA, but not risS, is required for maximal expression of Bvg-repressed genes.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species.FEMS microbiology reviews · 2026Review
- The contribution of BvgR, RisA, and RisS to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation inFrontiers in microbiology · 2024Article
- Interference of flagellar rotation up-regulates the expression of small RNA contributing toScience advances · 2022Article
- In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host.Nature communications · 2021Article
- Identification of a Genetically Linked but Functionally Independent Two-Component System Important for Cell Division of the Rice PathogenFrontiers in microbiology · 2021Article
- Integrated Signaling Pathways Mediate Bordetella Immunomodulation, Persistence, and Transmission.Trends in microbiology · 2019Review
- Signal transduction-dependent small regulatory RNA is involved in glutamate metabolism of the human pathogenRNA (New York, N.Y.) · 2018Article
- A Novel Bvg-Repressed Promoter CausesJournal of bacteriology · 2018Article
- Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.Medical microbiology and immunology · 2018Review
- Activation of Bvg-Repressed Genes in Bordetella pertussis by RisA Requires Cross Talk from Noncooperonic Histidine Kinase RisK.Journal of bacteriology · 2017Article
- The multifaceted RisA regulon of Bordetella pertussis.Scientific reports · 2016Article
- Evidence for a role of the polysaccharide capsule transport proteins in pertussis pathogenesis.PloS one · 2014Article
- A novel sensor kinase is required for Bordetella bronchiseptica to colonize the lower respiratory tract.Infection and immunity · 2011Article
- Intracellular trafficking of Bordetella pertussis in human macrophages.Infection and immunity · 2010Article
- The ChrA-ChrS and HrrA-HrrS signal transduction systems are required for activation of the hmuO promoter and repression of the hemA promoter in Corynebacterium diphtheriae.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Expression of virulence determinants by Bordetella pertussis, the primary etiological agent of whooping cough, is regulated by the BvgAS two-component regulatory system. The role of a second two-component regulatory system, encoded by risAS, in this process is not defined. Here, we show that mutation of B. pertussis risA does not affect Bvg-activated genes or proteins. However, mutation of risA resulted in greatly diminished expression of Bvg-repressed antigens and decreased transcription of Bvg-repressed genes. In contrast, mutation of risS had no effect on the expression of Bvg-regulated molecules. Mutation of risA also resulted in decreased bacterial invasion in a HeLa cell model. However, decreased invasion could not be attributed to the decreased expression of Bvg-repressed products, suggesting that mutation of risA may affect the expression of a variety of genes. Unlike the risAS operons in B. parapertussis and B. bronchiseptica, B. pertussis risS is a pseudogene that encodes a truncated RisS sensor. Deletion of the intact part of the B. pertussis risS gene does not affect the expression of risA-dependent, Bvg-repressed genes. These observations suggest that RisA activation occurs through cross-regulation by a heterologous system.
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