ArticleInfection and immunity2005
Helicobacter hepaticus hydrogenase mutants are deficient in hydrogen-supported amino acid uptake and in causing liver lesions in A/J mice.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.Microbiology and molecular biology reviews : MMBR · 2020Review
- Site-directed mutagenesis of Campylobacter concisus respiratory genes provides insight into the pathogen's growth requirements.Scientific reports · 2018Article
- Maturation of the [Ni-4Fe-4S] active site of carbon monoxide dehydrogenases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- Structure-function analyses of metal-binding sites of HypA reveal residues important for hydrogenase maturation in Helicobacter pylori.PloS one · 2017Article
- Carbon Fixation Driven by Molecular Hydrogen Results in Chemolithoautotrophically Enhanced Growth of Helicobacter pylori.Journal of bacteriology · 2016Article
- Host hydrogen rather than that produced by the pathogen is important for Salmonella enterica serovar Typhimurium virulence.Infection and immunity · 2015Article
- A link between gut community metabolism and pathogenesis: molecular hydrogen-stimulated glucarate catabolism aids Salmonella virulence.Open biology · 2013Article
- Helicobacter hepaticus NikR controls urease and hydrogenase activities via the NikABDE and HH0418 putative nickel import proteins.Microbiology (Reading, England) · 2013Article
- Roles of H2 uptake hydrogenases in Shigella flexneri acid tolerance.Microbiology (Reading, England) · 2012Article
- Efficiency of purine utilization by Helicobacter pylori: roles for adenosine deaminase and a NupC homolog.PloS one · 2012Article
- Hydrogen-stimulated carbon acquisition and conservation in Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2011Article
- Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer.Mucosal immunology · 2011Review
- Article
- Characterization of a Helicobacter hepaticus putA mutant strain in host colonization and oxidative stress.Infection and immunity · 2008Article
- The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus.Microbial pathogenesis · 2008Article
- Nickel enzyme maturation in Helicobacter hepaticus: roles of accessory proteins in hydrogenase and urease activities.Microbiology (Reading, England) · 2007Article
- Metal-responsive gene regulation and metal transport in Helicobacter species.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2007Review
- A Helicobacter hepaticus catalase mutant is hypersensitive to oxidative stress and suffers increased DNA damage.Journal of medical microbiology · 2007Article
- Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur.Infection and immunity · 2007Article
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Helicobacter hepaticus, a causative agent of chronic hepatitis and hepatocellular carcinoma in mice, expresses a nickel-containing hydrogen-oxidizing hydrogenase enzyme. Growth of a hyaB gene-targeted mutant was unaffected by the presence of hydrogen, unlike the wild-type strain, which showed an enhanced growth rate when supplied with H(2). Hydrogenase activities in H. hepaticus were constitutive and not dependent on the inclusion of H(2) during growth. Addition of nickel during growth significantly stimulated both urease (for wild-type and hyaB) and hydrogenase (for wild-type) activities. In a 5-h period, the extent of (14)C-labeled amino acid uptake by the wild type was markedly enhanced in the presence of hydrogen and was >5-fold greater than that of the hyaB mutant strain. In the presence of H(2), the short-term whole-cell amino acid uptake V(max) of the parent strain was about 2.2-fold greater than for the mutant, but the half-saturation affinity for amino acid transport was the same for the parent and mutant strain. The liver- and cecum-colonizing abilities of the strains was estimated by real-time PCR quantitation of the H. hepaticus-specific cytolethal distending toxin gene and showed similar animal colonization for the hyaB mutant and the wild type. However, at 21 weeks postinoculation, the livers from mice inoculated with wild type exhibited moderate lobular lymphoplasmacytic hepatitis with hepatocytic coagulative necrosis, but the hydrogenase mutants exhibited no histological evidence of lobular inflammation or necrosis.
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