ReviewEmergency medicine journal : EMJ2005
Naloxone in opioid poisoning: walking the tightrope.
Review in Emergency medicine journal : EMJ, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 190 citations in OpenAlex.
- Exploring drug-target interaction networks of illicit drugs.BMC genomics · 2013Pooled it
- Comparison of intranasal and intramuscular naloxone in opioid overdoses managed by ambulance staff: a double-dummy, randomised, controlled trial.Addiction (Abingdon, England) · 2022Trial
- A qualitative study of repeat naloxone administrations during opioid overdose intervention by people who use opioids in New York City.The International journal on drug policy · 2021Trial
- Factors associated with withdrawal symptoms and anger among people resuscitated from an opioid overdose by take-home naloxone: Exploratory mixed methods analysis.Journal of substance abuse treatment · 2020Trial
- Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers.European journal of clinical pharmacology · 2018Trial
- Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial.Drug and alcohol review · 2018Trial
- Randomized controlled pilot trial of naloxone-on-release to prevent post-prison opioid overdose deaths.Addiction (Abingdon, England) · 2017Trial
- Take-home emergency naloxone to prevent heroin overdose deaths after prison release: rationale and practicalities for the N-ALIVE randomized trial.Journal of urban health : bulletin of the New York Academy of Medicine · 2013Trial
- Naloxone dosing by non-medical first-responders at opioid overdoses: findings from a qualitative interview study.Harm reduction journal · 2025Article
- Pharmacological modulation of respiratory control: Ampakines as a therapeutic strategy.Pharmacology & therapeutics · 2025Review
- Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence).Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Nanotechnology-Enhanced Naloxone and Alternative Treatments for Opioid Addiction.ACS pharmacology & translational science · 2024Review
- High-dose naloxone formulations are not as essential as we thought.Harm reduction journal · 2024Review
- Acute opioid overdose in pediatric patients.Journal of the American College of Emergency Physicians open · 2024Article
- Clinical Pharmacokinetics and Pharmacodynamics of Naloxone.Clinical pharmacokinetics · 2024Review
- Self-discharge during treatment for acute recreational drug toxicity: an observational study from emergency departments in seven European countries.International journal of emergency medicine · 2023Article
- Amphetamines modulate fentanyl-depressed respiration in a bidirectional manner.Drug and alcohol dependence · 2023Article
- Comparing Two Naloxone Tapering Methods in Management of Methadone Intoxication; a Quasi-experimental Study.Archives of academic emergency medicine · 2023Article
- Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development.Human vaccines & immunotherapeutics · 2022Article
- Predicting the efficacy of opioid sequestration by intravenous lipid emulsion using biologically relevant in vitro models of drug distribution.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute opioid intoxication and overdose are common causes of presentation to emergency departments. Although naloxone, a pure opioid antagonist, has been available for many years, there is still confusion over the appropriate dose and route of administration. This article looks at the reasons for this uncertainty and undertakes a literature review from which a treatment algorithm is presented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.