ReviewArchives of disease in childhood. Fetal and neonatal edition2005
Feeding growth restricted preterm infants with abnormal antenatal Doppler results.
Review in Archives of disease in childhood. Fetal and neonatal edition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 6 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- A systematic review and meta-analysis of the role of Doppler ultrasonography of the superior mesenteric artery in detecting neonates at risk of necrotizing enterocolitis.Pediatric radiology · 2023Pooled it
- Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.The Cochrane database of systematic reviews · 2021Pooled it
- Early full enteral feeding for preterm or low birth weight infants.The Cochrane database of systematic reviews · 2020Pooled it
- Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.The Cochrane database of systematic reviews · 2017Pooled it
- Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants.The Cochrane database of systematic reviews · 2014Pooled it
- Early trophic feeding versus enteral fasting for very preterm or very low birth weight infants.The Cochrane database of systematic reviews · 2013Pooled it
- Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- ADEPT - Abnormal Doppler Enteral Prescription Trial.BMC pediatrics · 2009Trial
- Early versus Late Initiation of Enteral Feeding in Premature Infants (28-34 Weeks GA) with Growth Restriction and Absent or Reversed End-Diastolic Flow on Umbilical Artery Doppler: A Randomised Controlled Trial.Indian journal of pediatrics · 2026Article
- Machine learning demonstrates normal fetal Doppler velocimetry associated with reduced risk of necrotizing enterocolitis among preterm infants with growth restriction.Journal of neonatal-perinatal medicine · 2026Article
- Feeding challenges in larger versus smaller preterm discordant twins.Frontiers in pediatrics · 2026Article
- Optimizing Nutrition in Extremely Low Gestational Age Neonates: An Evidence-Based Protocol.Indian journal of pediatrics · 2025Review
- Prevention Strategies and Management of Necrotizing Enterocolitis.Current treatment options in pediatrics · 2024Article
- [Expert consensus on enteral nutrition management for preterm infants in special situations (2024)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Nutritional Strategies for Preterm Neonates and Preterm Neonates Undergoing Surgery: New Insights for Practice and Wrong Beliefs to Uproot.Nutrients · 2024Review
- Classification and Special Nutritional Needs of SGA Infants and Neonates of Multiple Pregnancies.Nutrients · 2023Review
- Twinning as a risk factor for neonatal acute intestinal diseases: a case-control study.Frontiers in pediatrics · 2023Article
- Association between Abnormal Antenatal Doppler Characteristics and Gastrointestinal Outcomes in Preterm Infants.Nutrients · 2022Article
- Time to occurrence of necrotizing enterocolitis and its predictors among low birth weight neonates admitted at neonatal intensive care unit of felege hiwot compressive specialized hospital BahirDar, Ethiopia, 2021: A retrospective follow-up study.Frontiers in pediatrics · 2022Article
- Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Absence or reversal of end diastolic flow (AREDF) in the umbilical artery is associated with poor outcome, and elective premature delivery is common. Feeding these infants is a challenge. They often have poor tolerance of enteral feeding, and necrotising enterocolitis may develop. This review explores current practice to see if there is evidence on which to base guidelines. The incidence of necrotising enterocolitis is increased in infants with fetal AREDF, especially when complicated by fetal growth restriction. Abnormalities of splanchnic blood flow persist postnatally, with some recovery during the first week of life, providing justification for a delayed and careful introduction of enteral feeding. Such a policy exposes babies to the risks of parenteral nutrition, with no trials to date showing any benefit of delayed enteral nutrition. Trials are required to determine the optimum timing for introduction of enteral feeds in growth restricted infants with fetal AREDF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.