ArticleBiophysical journal2005
Cyclical interactions between two outer doublet microtubules in split flagellar axonemes.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 64 citations in OpenAlex.
- Structural determination and modeling of ciliary microtubules.Acta crystallographica. Section D, Structural biology · 2024Review
- Article
- Active beating modes of two clamped filaments driven by molecular motors.Journal of the Royal Society, Interface · 2022Article
- Steady dynein forces induce flutter instability and propagating waves in mathematical models of flagella.Journal of the Royal Society, Interface · 2016Article
- The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme.Cytoskeleton (Hoboken, N.J.) · 2016Article
- A computational model of dynein activation patterns that can explain nodal cilia rotation.Biophysical journal · 2015Article
- Engaging the "clutch" to move forward.Biophysical journal · 2014Article
- Dynein regulation: going into circles can set things straight.Biophysical journal · 2014Article
- Motor regulation results in distal forces that bend partially disintegrated Chlamydomonas axonemes into circular arcs.Biophysical journal · 2014Article
- The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes.Molecular biology of the cell · 2013Article
- Simulation of cyclic dynein-driven sliding, splitting, and reassociation in an outer doublet pair.Biophysical journal · 2009Article
- Heart of the beat (the flagellar beat, that is).Biophysical journal · 2009Article
- Regulation of dynein-driven microtubule sliding by the axonemal protein kinase CK1 in Chlamydomonas flagella.The Journal of cell biology · 2009Article
- Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility.Molecular biology of the cell · 2006Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The beating of cilia and flagella is based on the localized sliding between adjacent outer doublet microtubules; however, the mechanism that produces oscillatory bending is unclear. To elucidate this mechanism, we examined the behavior of frayed axonemes of Chlamydomonas by using high-speed video recording. A pair of doublet microtubules frequently displayed association and dissociation cycles in the presence of ATP. In many instances, the dissociation of two microtubules was not accompanied by noticeable bending, suggesting that the dynein-microtubule interaction is not necessarily regulated by the microtubule curvature. On rare occasions, association and dissociation occurred simultaneously in the same interacting pair, resulting in a tip-directed movement of a stretch of gap between the pair. Based on these observations, we propose a model for cyclical bend propagation in the axoneme.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.