ArticleBiophysical journal2005
Variability in couplon size in rabbit ventricular myocytes.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CaJournal of molecular and cellular cardiology · 2023Article
- Structural variability of dyads relates to calcium release in rat ventricular myocytes.Scientific reports · 2020Article
- Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814.The Journal of physiology · 2016Article
- Ryanodine receptor gating controls generation of diastolic calcium waves in cardiac myocytes.The Journal of general physiology · 2015Article
- Calcium alternans in cardiac myocytes: order from disorder.Journal of molecular and cellular cardiology · 2013Review
- CaV1.2 sparklets in heart and vascular smooth muscle.Journal of molecular and cellular cardiology · 2013Review
- The interaction of Ca2+ with sarcomeric proteins: role in function and dysfunction of the heart.American journal of physiology. Heart and circulatory physiology · 2012Review
- Multi-scale modeling in biology: how to bridge the gaps between scales?Progress in biophysics and molecular biology · 2011Review
- Alternans and arrhythmias: from cell to heart.Circulation research · 2011Review
- Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes.Biophysical journal · 2010Article
- Frequency and release flux of calcium sparks in rat cardiac myocytes: a relation to RYR gating.The Journal of general physiology · 2010Article
- There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling.Journal of biomedicine & biotechnology · 2010Review
- Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes.The Journal of physiology · 2008Article
- Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes.Biophysical journal · 2008Article
- Kinetics of calcium spikes in rat cardiac myocytes.The Journal of physiology · 2007Article
- Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux.Circulation research · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Variation in couplon size is thought to be essential for graded Ca(2+) transients in cardiac myocytes. We examined this variation by investigating spark appearance in rabbit ventricular myocytes at various locations and at potentials from -20 to 0 mV. At 0 mV, sparks appeared at the beginning of the voltage step with a probability of unity. On the other hand, at -20 mV, sparks appeared later during the voltage step with a lower probability. The cumulative spark probabilities at various potentials were fitted with exponential functions of both time and voltage. Spark latency became longer as spark probability decreased at more negative potentials. At -20 mV, the cumulative spark probability and the mean spark latency were not only variable among locations but also inversely related. Under the assumption that a single opening of an L-type Ca(2+) channel triggers a spark, we suggest a simple mathematical explanation for the distribution of spark appearance. The variation in spark probability and latency with location suggests that the couplon size, and hence the number of L-type Ca(2+) channels in a couplon is variable.
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