ArticleBiophysical journal2005
Direct mechanical force measurements during the migration of Dictyostelium slugs using flexible substrata.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanobiology of the tumor microenvironment: a review of therapeutic interactions and in vitro elasticity measurement techniques.Journal of biomedical science · 2026Review
- Dynamics of centipede locomotion revealed by large-scale traction force microscopy.Journal of the Royal Society, Interface · 2024Article
- Differential cell motion: A mathematical model of anterior posterior sorting.Biophysical journal · 2023Article
- Rear traction forces drive adherent tissue migration in vivo.Nature cell biology · 2022Article
- Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment.Journal of the Royal Society, Interface · 2019Article
- Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons fromInterface focus · 2016Review
- Coordination of contractility, adhesion and flow in migrating Physarum amoebae.Journal of the Royal Society, Interface · 2015Article
- Mechanics of peristaltic locomotion and role of anchoring.Journal of the Royal Society, Interface · 2012Article
- Macroscopic stiffening of embryonic tissues via microtubules, RhoGEF and the assembly of contractile bundles of actomyosin.Development (Cambridge, England) · 2010Article
- Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Transport of a 1D viscoelastic actin-myosin strip of gel as a model of a crawling cell.Physica A · 2006Article
- Imaging of cell migration.The EMBO journal · 2006Review
- An iterative method to calculate forces exerted by single cells and multicellular assemblies from the detection of deformations of flexible substrates.European biophysics journal : EBJ · 2006Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We use the flexible substrate method to study how and where mechanical forces are exerted during the migration of Dictyostelium slugs. This old and contentious issue has been left poorly understood so far. We are able to identify clearly separate friction forces in the tip and in the tail of the slug, traction forces mostly localized in the inner slug/surface contact area in the prespore region and large perpendicular forces directed in the outward direction at the outline of contact area. Surprisingly, the magnitude of friction and traction forces is decreasing with slug velocity indicating that these quantities are probably related to the dynamics of cell/substrate adhesion complexes. Contrary to what is always assumed in models and simulations, friction is not of fluid type (viscous drag) but rather close to solid friction. We suggest that the slime sheath confining laterally the cell mass of the slug experiences a tension that in turn is pulling out the elastic substrate in the direction tangential to the slug profile where sheath is anchored. In addition, we show in the appendix that the iterative method we developed is well adapted to study forces over large and continuous fields when the experimental error is sufficiently low and when the plane of recorded bead deformations is close enough to the elastomer surface, requirements fulfilled in this experimental study of Dictyostelium slugs.
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