ArticleNeurobiology of aging2006
Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study.
Article in Neurobiology of aging, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Presynaptic compensation sustains neuromuscular transmission in the mouse diaphragm at a late stage of aging.Biogerontology · 2026Article
- Review
- How muscle ageing affects rapid goal-directed movement: mechanistic insights from a simple model.PLoS computational biology · 2026Article
- The Muscle Function Deficit Concept and Inflammaging.Biomedicines · 2026Article
- The Role of Novel Biomarkers in the Early Management of Peripheral Diabetic Neuropathy.Central nervous system agents in medicinal chemistry · 2026Review
- Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results.GeroScience · 2025Article
- Blood Cell Count-Based Inflammatory Markers Exhibit Superior Association with Diabetic Peripheral Neuropathy Compared to Protein-Based Markers.Journal of inflammation research · 2025Article
- Association of Elevated Serum Uric Acid with Nerve Conduction Function and Peripheral Neuropathy Stratified by Gender and Age in Type 2 Diabetes Patients.Brain sciences · 2022Article
- Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults.GeroScience · 2021Article
- Immunity to acute virus infections with advanced age.Current opinion in virology · 2021Review
- Cardiometabolic risk factors as determinants of peripheral nerve function: the Maastricht Study.Diabetologia · 2020Article
- Article
- Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey.Somatosensory & motor research · 2018Article
- Successful aging: Advancing the science of physical independence in older adults.Ageing research reviews · 2015Review
- Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Serial anthropometry predicts peripheral nerve dysfunction in a community cohort.Diabetes/metabolism research and reviews · 2013Article
- Aging and muscle: a neuron's perspective.Current opinion in clinical nutrition and metabolic care · 2013Review
- Role of muscle mass and muscle quality in the association between diabetes and gait speed.Diabetes care · 2012Article
- Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.Journal of the American Medical Directors Association · 2011Article
- Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.American journal of human genetics · 2009Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundAging of the peripheral nervous system is associated with several morphologic and functional changes, including a decrease of the nerve conduction velocity. There is evidence that these changes contribute to age-related-decline in muscle strength, sensory discrimination, and autonomic responses. The aim of this study was to characterize the decline in nerve conduction velocity in the peripheral nervous system over the aging process and to identify factors that, independent of age, affect nerve conduction velocity.
methodsWe measured motor nerve conduction velocity of the right superficial peroneal nerve using a standard neurophysiologic technique in a population-based sample of subjects aged between 20 and 103 years old enrolled in the InCHIANTI study.
resultsAverage conduction velocities in the peripheral nerve decreased linearly with age in both sexes. We found that diabetes, cognitive impairment, uric acid, sIL-6R and alpha-tocopherol were significant predictors of nerve conduction velocity independently of the potential confounding effect of age, sex, sex x age interaction term, height, lymphocytes, neutrophils number, alpha1 and alpha2-globulin serum protein.
conclusionsOur findings are consistent with the hypothesis that inflammation and inadequate antioxidant defenses are associated with accelerated decline of nerve conduction velocity over the aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.