ArticleBMC cancer2005
Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs.
Article in BMC cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Pooled it
- An in silico approach for screening non-synonymous SNPs in Mycobacterium tuberculosis PPE68 protein and impact on structure.Scientific reports · 2025Article
- Protein Phosphorylation Response to Abiotic Stress in Plants.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Shedding Light on the Interaction of Human Anti-Apoptotic Bcl-2 Protein with Ligands through Biophysical and in Silico Studies.International journal of molecular sciences · 2019Article
- Gender-Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population.Yonsei medical journal · 2017Article
- Impact of SNPs on Protein Phosphorylation Status in Rice (Oryza sativa L.).International journal of molecular sciences · 2016Article
- Screening of the BRCA1 gene in Brazilian patients with breast and/or ovarian cancer via high-resolution melting reaction analysis.Familial cancer · 2016Article
- MIMP: predicting the impact of mutations on kinase-substrate phosphorylation.Nature methods · 2015Article
- Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2.PloS one · 2013Article
- Part 4: pharmacogenetic variability in anticancer pharmacodynamic drug effects.The oncologist · 2011Review
- PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation.Molecular & cellular proteomics : MCP · 2010Article
- Can genes for mammographic density inform cancer aetiology?Nature reviews. Cancer · 2008Review
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2 authors.
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Abstract
backgroundPhosphorylation is a reversible post-translational modification that affects the intrinsic properties of proteins, such as structure and function. Non-synonymous single nucleotide polymorphisms (nsSNPs) result in the substitution of the encoded amino acids and thus are likely to alter the phosphorylation motifs in the proteins.
methodsIn this study, we used the web-based NetPhos tool to predict candidate nsSNPs that either introduce or remove putative phosphorylation sites in proteins that act in DNA repair and cell cycle pathways.
resultsOur results demonstrated that a total of 15 nsSNPs (16.9%) were likely to alter the putative phosphorylation patterns of 14 proteins. Three of these SNPs (CDKN1A-S31R, OGG1-S326C, and XRCC3-T241M) have already found to be associated with altered cancer risk. We believe that this set of nsSNPs constitutes an excellent resource for further molecular and genetic analyses.
conclusionThe novel systematic approach used in this study will accelerate the understanding of how naturally occurring human SNPs may alter protein function through the modification of phosphorylation mechanisms and contribute to disease susceptibility.
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