Trial reportDigestive diseases and sciences2005
A follow-up study on the effect of Helicobacter pylori eradication on the severity of gastric histology.
Trial report in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- AGA Technical Review on Gastric Intestinal Metaplasia-Natural History and Clinical Outcomes.Gastroenterology · 2020Pooled it
- Association between vacA genotypes and the risk of duodenal ulcer: a meta-analysis.Molecular biology reports · 2014Pooled it
- Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis.World journal of gastroenterology · 2014Pooled it
- Is a 7-day Helicobater pylori treatment enough for eradication and inactivation of gastric inflammatory activity?World journal of gastroenterology · 2008Trial
- The Effect ofJournal of clinical medicine · 2021Review
- Anti-Laboratory animal research · 2020Article
- Article
- Anti-Laboratory animal research · 2018Article
- Association between Gastric Cancer Risk and SerumGastroenterology research and practice · 2017Article
- Helicobacter pylori Antibody Titer and Gastric Cancer Screening.Disease markers · 2015Review
- Capsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with H. pylori gastritis.World journal of gastrointestinal pharmacology and therapeutics · 2011Article
- Gastric carcinogenesis.Langenbeck's archives of surgery · 2011Review
- Helicobacter pylori and gastric cancer in the Middle East: a new enigma?World journal of gastroenterology · 2010Review
- The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Antralization of the gastric mucosa of the incisura angularis and its gastrin expression.International journal of clinical and experimental pathology · 2009Article
- In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model.International journal of medical sciences · 2007Article
- Participation of capsaicin-sensitive afferent nerves in the gastric mucosa of patients with Helicobacter pylori-positive or-negative chronic gastritis.Digestive diseases and sciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori genetic diversity and geographic distribution affect the severity of gastric histology; while eradication heals gastritis, the improvement of atrophy and intestinal metaplasia (IM) is still controversial. We investigated whether H. pylori infection and genotypes (cagA-vacA) influence the histological changes and whether eradication resolves these changes. Twenty-one patients (11 duodenal ulcer, 2 gastric ulcer, 8 gastritis) received treatment. Biopsies for CLO, PCR, histology, and culture were collected before and at 1 and 12 months after treatment, and serum samples at 0, 1, 2, 6, and 12 months. H. pylori eradication was achieved in 71% of the patients. Histological scores for H. pylori densities were significantly higher in the antrum and incisura angularis. Scores for mononuclear cell and neutrophil infiltration were significantly higher in regions with a high H. pylori density and improved progressively after eradication. Eight patients with atrophy including five with IM showed no significant changes 12 months after eradication. The cagA gene, detected in 13 (62%), the vacA-sla gene, in 20 (95%), and the vacA-m1 gene, in 12 (57%) of 21 patients were significantly associated with duodenal ulcer. A gradual decline in antibody titer reached an average of 67% 12 months after eradication. H. pylori infection and the associated genotypes (cagA of Western type) affect the severity of the gastric histology (mild forms of atrophy and IM) and the disease outcome. Eradication of H. pylori resulted in healing of gastritis, but with no significant improvement in atrophy or IM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.