Trial reportDigestive diseases and sciences2005
Acid challenge to the human esophageal mucosa: effects on epithelial architecture in health and disease.
Trial report in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis.Clinics (Sao Paulo, Brazil) · 2009Trial
- Expression of inducible nitric oxide synthase, nitrotyrosine, eosinophilic peroxidase, eotaxin-3, and galectin-3 in patients with gastroesophageal reflux disease, eosinophilic esophagitis, and in healthy controls: a semiquantitative image analysis of 3,3'-diaminobenzidine-stained esophageal biopsies.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024Article
- Latin American consensus on diagnosis of gastroesophageal reflux disease.Neurogastroenterology and motility · 2024Article
- A reduced esophageal epithelial integrity in a subgroup of healthy individuals increases with proton pump inhibitor therapy.United European gastroenterology journal · 2018Article
- Dilated intercellular spaces and chronic cough as an extra-oesophageal manifestation of gastrooesophageal reflux disease.Pulmonary pharmacology & therapeutics · 2011Article
- Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease.The American journal of gastroenterology · 2011Article
- Cystitis, co-morbid disorders and associated epithelial dysfunction.Neurourology and urodynamics · 2011Review
- Role of corticotrophin-releasing factor in the stress-induced dilation of esophageal intercellular spaces.Journal of Korean medical science · 2011Article
- The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms.Best practice & research. Clinical gastroenterology · 2010Review
- Dilated intercellular spaces as a marker of GERD.Current gastroenterology reports · 2009Review
- Article
- [Latin American Consensus on the Diagnosis of Gastroesophageal Reflux Disease].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The histological changes that occur in the squamous epithelium in response to acute acid challenge was examined in healthy controls and proton pump inhibitor-treated gastroesophageal reflux disease (GERD) patients and related to the state of untreated erosive GERD in a saline-controlled, randomized perfusion study. In the basal state a stepwise significant increase in the thickness of the basal cell layer, papillary length, and dilatation of intercellular spaces (DIS) was seen when the three groups were compared. Acid perfusion induced a slight increase in the height of the basal cell layer mainly in healthy volunteers; this layer appears to be reactive to acute acid challenge as well as to acid suppressive therapy. DIS increases promptly in response to acute acid exposure in the healthy epithelium but no changes were seen in the lengths of the papillae or regarding DIS in the GERD patients. A protective effect of luminal nitric oxide on DIS development is suggested.
Indexed as
Identifiers
16110841What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.