ArticleJournal of bacteriology2005
Regulation of the Bacillus subtilis ytmI operon, involved in sulfur metabolism.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptome Sequencing Reveals Distinct Stress Response of Listeria monocytogenes 6179 During Logarithmic and Stationary Growth Phases.MicrobiologyOpen · 2025Article
- Inactivation of the conserved protease LonA increases production of xylanase and amylase in Bacillus subtilis.Microbial cell factories · 2024Article
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- Identification of a metabolic disposal route for the oncometaboliteThe Journal of biological chemistry · 2018Article
- A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Relationship of proteomic variation and toxin synthesis in the dinoflagellate Alexandrium tamarense CI01 under phosphorus and inorganic nitrogen limitation.Ecotoxicology (London, England) · 2015Article
- A systematic proteomic analysis of Listeria monocytogenes house-keeping protein secretion systems.Molecular & cellular proteomics : MCP · 2014Article
- TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans.FEMS microbiology letters · 2012Article
- Article
- Global regulation of gene expression in response to cysteine availability in Clostridium perfringens.BMC microbiology · 2010Article
- Three paralogous LysR-type transcriptional regulators control sulfur amino acid supply in Streptococcus mutans.Journal of bacteriology · 2010Article
- Time-resolved transcriptome analysis of Bacillus subtilis responding to valine, glutamate, and glutamine.PloS one · 2009Article
- The LysR-type transcriptional regulator YofA controls cell division through the regulation of expression of ftsW in Bacillus subtilis.Journal of bacteriology · 2007Article
- Conversion of methionine to cysteine in Bacillus subtilis and its regulation.Journal of bacteriology · 2007Article
- The global regulator Spx functions in the control of organosulfur metabolism in Bacillus subtilis.Journal of bacteriology · 2006Article
- Global control of cysteine metabolism by CymR in Bacillus subtilis.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The YtlI regulator of Bacillus subtilis activates the transcription of the ytmI operon encoding an l-cystine ABC transporter, a riboflavin kinase, and proteins of unknown function. The expression of the ytlI gene and the ytmI operon was high with methionine and reduced with sulfate. Using deletions and site-directed mutagenesis, a cis-acting DNA sequence important for YtlI-dependent regulation was identified upstream from the -35 box of ytmI. Gel mobility shift assays confirmed that YtlI specifically interacted with this sequence. The replacement of the sulfur-regulated ytlI promoter by the xylA promoter led to constitutive expression of a ytmI'-lacZ fusion in a ytlI mutant, suggesting that the repression of ytmI expression by sulfate was mainly at the level of YtlI synthesis. We further showed that the YrzC regulator negatively controlled ytlI expression while this repressor also acted on ytmI expression via YtlI. The cascade of regulation observed in B. subtilis is conserved in Listeria spp. Both a YtlI-like regulator and a ytmI-type operon are present in Listeria spp. Indeed, the Lmo2352 protein from Listeria monocytogenes was able to replace YtlI for the activation of ytmI expression and a lmo2352'-lacZ fusion was repressed in the presence of sulfate via YrzC in B. subtilis. A common motif, AT(A/T)ATTCCTAT, was found in the promoter region of the ytlI and lmo2352 genes. Deletion of part of this motif or the introduction of point mutations in this sequence confirmed its involvement in ytlI regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.