ArticleJournal of bacteriology2005
Cytochrome c maturation and the physiological role of c-type cytochromes in Vibrio cholerae.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The role of cytochrome oxidases in bacterial virulence.Infection and immunity · 2026Review
- Article
- Vibrio natriegens as a superior host for the production of c-type cytochromes and difficult-to-express redox proteins.Scientific reports · 2024Article
- Intestinal colonization againstAIMS microbiology · 2023Review
- Experimental evolution ofFrontiers in microbiology · 2022Article
- On or Off: Life-Changing Decisions Made byInfectious microbes & diseases · 2020Review
- Genetic Dissection of the Fermentative and Respiratory Contributions Supporting Vibrio cholerae Hypoxic Growth.Journal of bacteriology · 2020Article
- A Hybrid Extracellular Electron Transfer Pathway Enhances the Survival of Vibrio natriegens.Applied and environmental microbiology · 2020Article
- Article
- Adaptation ofFrontiers in microbiology · 2020Review
- Antibiotic Korormicin A Kills Bacteria by Producing Reactive Oxygen Species.Journal of bacteriology · 2019Article
- Anaerobic nitrate reduction divergently governs population expansion of the enteropathogen Vibrio cholerae.Nature microbiology · 2018Article
- Oxidative stress, protein damage and repair in bacteria.Nature reviews. Microbiology · 2017Review
- Article
- The Vibrio cholerae Cpx envelope stress response senses and mediates adaptation to low iron.Journal of bacteriology · 2015Article
- A biochemical approach to study the role of the terminal oxidases in aerobic respiration in Shewanella oneidensis MR-1.PloS one · 2014Article
- Life based on phosphite: a genome-guided analysis of Desulfotignum phosphitoxidans.BMC genomics · 2013Article
- Activation of cholera toxin production by anaerobic respiration of trimethylamine N-oxide in Vibrio cholerae.The Journal of biological chemistry · 2012Article
- Physiological function of soluble cytochrome c-552 from alkaliphilic Pseudomonas alcaliphila AL15-21(T).Journal of bioenergetics and biomembranes · 2011Article
- The diheme cytochrome c(4) from Vibrio cholerae is a natural electron donor to the respiratory cbb(3) oxygen reductase.Biochemistry · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio cholerae lives in different habitats, varying from aquatic ecosystems to the human intestinal tract. The organism has acquired a set of electron transport pathways for aerobic and anaerobic respiration that enable adaptation to the various environmental conditions. We have inactivated the V. cholerae ccmE gene, which is required for cytochrome c biogenesis. The resulting strain is deficient of all c-type cytochromes and allows us to characterize the physiological role of these proteins. Under aerobic conditions in rich medium, V. cholerae produces at least six c-type cytochromes, none of which is required for growth. Wild-type V. cholerae produces active fumarate reductase, trimethylamine N-oxide reductase, cbb3 oxidase, and nitrate reductase, of which only the fumarate reductase does not require maturation of c-type cytochromes. The reduction of nitrate in the medium resulted in the accumulation of nitrite, which is toxic for the cells. This suggests that V. cholerae is able to scavenge nitrate from the environment only in the presence of other nitrite-reducing organisms. The phenotypes of cytochrome c-deficient V. cholerae were used in a transposon mutagenesis screening to search for additional genes required for cytochrome c maturation. Over 55,000 mutants were analyzed for nitrate reductase and cbb3 oxidase activity. No transposon insertions other than those within the ccm genes for cytochrome c maturation and the dsbD gene, which encodes a disulphide bond reductase, were found. In addition, the role of a novel CcdA-like protein in cbb3 oxidase assembly is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.