ArticleImmunology2005
Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation.
Article in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Article
- Article
- Integrated comparison of the mRNAome in cartilage, synovium, and macrophages in osteoarthritis.Zeitschrift fur Rheumatologie · 2024Article
- PIM1 signaling in immunoinflammatory diseases: an emerging therapeutic target.Frontiers in immunology · 2024Review
- PIM kinases regulate early human Th17 cell differentiation.Cell reports · 2023Article
- An overview of pim kinase as a target in multiple myeloma.Cancer medicine · 2023Review
- Review
- The Role of PIM Kinases in Pediatric Solid Tumors.Cancers · 2022Review
- HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART.JCI insight · 2022Article
- Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis.JCI insight · 2022Article
- Feedback Loop Regulation between Pim Kinases and Tax Keeps Human T-Cell Leukemia Virus Type 1 Viral Replication in Check.Journal of virology · 2022Article
- PIM Kinases in Multiple Myeloma.Cancers · 2021Review
- The role of Pim kinase in immunomodulation.American journal of cancer research · 2020Review
- Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.Journal of cellular and molecular medicine · 2018Article
- Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.Oncotarget · 2017Article
- Transcriptional and epigenetic regulation of T-helper lineage specification.Immunological reviews · 2014Review
- Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.The Journal of biological chemistry · 2013Article
- Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia.PloS one · 2013Article
- Inhibition of Pim2-prolonged skin allograft survival through the apoptosis regulation pathway.Cellular & molecular immunology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines are the most important inducers of T helper (Th) cell differentiation. Interleukin-12 (IL-12) and interferon-alpha (IFN-alpha) are responsible for human Th1-cell differentiation, while IL-4 is the critical cytokine promoting Th2-cell development. These two subsets of cells co-ordinate immunological responses to pathogens as well as autoimmune or allergic reactions. The pim family of proto-oncogenes encodes serine/threonine-specific kinases involved in cytokine-mediated signalling pathways in haematopoietic cells. Here we demonstrate that expression of pim-1 and pim-2 mRNAs is selectively up- or down-regulated in human cord-blood-derived CD4+ cells freshly induced to polarize towards Th1 or Th2 cells, respectively, whereas their expression is inhibited in both cell types by the immunosuppressive transforming growth factor beta (TGF-beta). Moreover, the Th1-specific cytokines IL-12 and IFN-alpha, but not the Th2-specific cytokine IL-4, transiently up-regulate pim-1 and pim-2 mRNA expression in human peripheral blood T cells and natural killer cells. In addition, the Pim-1 protein levels are strongly up-regulated by Th1-specific cytokines in all of these cell types. Taken together, our results suggest that pim genes and their protein products are involved in the early differentiation process of T helper cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.