ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2005
Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- The burden of respiratory syncytial virus in adults: a systematic review and meta-analysis.Epidemiology and infection · 2020Pooled it
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- Annual trends in Google searches provides insights related to rhinosinusitis exacerbations.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Clinical metagenomics assessments improve diagnosis and outcomes in community-acquired pneumonia.BMC infectious diseases · 2021Article
- Case study-based time-course analysis of symptoms of respiratory syncytial virus infections followed by acute sinusitis in otherwise-healthy adults.Journal of thoracic disease · 2018Article
- Establishing an ICD-10 code based SARI-surveillance in Germany - description of the system and first results from five recent influenza seasons.BMC public health · 2017Article
- Role of Clinicogenomics in Infectious Disease Diagnostics and Public Health Microbiology.Journal of clinical microbiology · 2016Article
- Evaluation of a PCR/ESI-MS platform to identify respiratory viruses from nasopharyngeal aspirates.Journal of medical virology · 2015Article
- Non-culturable bioaerosols in indoor settings: Impact on health and molecular approaches for detection.Atmospheric environment (Oxford, England : 1994) · 2015Article
- Respiratory viruses in airline travellers with influenza symptoms: Results of an airport screening study.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
- Surveillance and clinical characterization of influenza in a university cohort in Singapore.PloS one · 2015Article
- Impaired immune response to vaccination against infection with human respiratory syncytial virus at advanced age.Journal of virology · 2014Article
- A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples.Genome research · 2014Article
- Working-age adults with diabetes experience greater susceptibility to seasonal influenza: a population-based cohort study.Diabetologia · 2014Article
- Ten year retrospective evaluation of the seasonal distribution of agent viruses in childhood respiratory tract infections.Turk pediatri arsivi · 2014Article
- Prospective surveillance and molecular characterization of seasonal influenza in a university cohort in Singapore.PloS one · 2014Article
- Phylogenetic patterns of human coxsackievirus B5 arise from population dynamics between two genogroups and reveal evolutionary factors of molecular adaptation and transmission.Journal of virology · 2013Article
- Influenza testing, diagnosis, and treatment in the emergency department in 2009-2010 and 2010-2011.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2013Article
- Human metapneumovirus (hMPV) in acute respiratory infection: a clinic-based study in Egypt.Indian journal of pediatrics · 2012Article
- The post-infection outcomes of influenza and acute respiratory infection in patients above 50 years of age in Japan: an observational study.Influenza and other respiratory viruses · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith use of polymerase chain reaction (PCR) and a centrifugation-enhanced viral culture method, we characterized the viruses causing acute respiratory infection in adults during an influenza season.
methodsDuring January-March 2002, nasopharyngeal wash specimens from previously healthy adults presenting with respiratory symptoms were evaluated for viral pathogens with centrifugation-enhanced viral culture and PCR.
resultsThe diagnoses in 266 cases included unspecified upper respiratory infection (in 142 [54%] of the cases), acute bronchitis (42 [16%]), sinusitis (23 [9%]), pharyngitis (22 [8%]), and pneumonia (17 [6%]). The use of a shell vial assay and PCR identified a pathogen in 103 (39%) of the patients, including influenza A or B in 54, picornavirus in 28 (including rhinovirus in 24), respiratory syncytial virus (RSV) in 12, human metapneumovirus in 4, human coronavirus OC43 in 2, adenovirus in 2, parainfluenza virus type 1 in 1, and coinfection with influenza and parainfluenza virus type 1 in 2.
conclusionOur findings demonstrate that, even during the influenza season, rhinovirus and RSV are prevalent and must be considered in the differential diagnosis of adult acute respiratory infection before prescribing antiviral medication. Human coronavirus and human metapneumovirus did not play a substantial role. PCR was an especially useful tool in the identification of influenza and other viral pathogens not easily detected by traditional testing methods.
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