ArticleThe EMBO journal2005
The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
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- Help or hindrance: how do microtubule-based forces contribute to genome damage and repair?Current genetics · 2020Review
- Protein phosphatases of Saccharomyces cerevisiae.Current genetics · 2019Review
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- Membrane curvature directs the localization of Cdc42p to novel foci required for cell-cell fusion.The Journal of cell biology · 2017Article
- Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis.The Journal of biological chemistry · 2014Article
- The cell end marker Tea4 regulates morphogenesis and pathogenicity in the basidiomycete fungus Ustilago maydis.Fungal genetics and biology : FG & B · 2014Article
- Substrate analysis of the Pneumocystis carinii protein kinases PcCbk1 and PcSte20 using yeast proteome microarrays provides a novel method for Pneumocystis signalling biology.Yeast (Chichester, England) · 2011Article
- Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma.Cell cycle (Georgetown, Tex.) · 2010Article
- Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Function of dynein in budding yeast: mitotic spindle positioning in a polarized cell.Cell motility and the cytoskeleton · 2009Review
- Dynein-driven mitotic spindle positioning restricted to anaphase by She1p inhibition of dynactin recruitment.Molecular biology of the cell · 2009Article
- Spindle orientation during asymmetric cell division.Nature cell biology · 2009Review
- Displacement of formins from growing barbed ends by bud14 is critical for actin cable architecture and function.Developmental cell · 2009Article
- Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.Eukaryotic cell · 2008Article
- Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7.BMC genomics · 2008Article
- Kelch repeat protein Clakel2p and calcium signaling control appressorium development in Colletotrichum lagenarium.Eukaryotic cell · 2008Article
- Nucleocytoplasmic trafficking is required for functioning of the adaptor protein Sla1p in endocytosis.Traffic (Copenhagen, Denmark) · 2007Article
- Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Regulated interactions between microtubules (MTs) and the cell cortex control MT dynamics and position the mitotic spindle. In eukaryotic cells, the adenomatous polyposis coli/Kar9p and dynein/dynactin pathways are involved in guiding MT plus ends and MT sliding along the cortex, respectively. Here we identify Bud14p as a novel cortical activator of the dynein/dynactin complex in budding yeast. Bud14p accumulates at sites of polarized growth and the mother-bud neck during cytokinesis. The localization to bud and shmoo tips requires an intact actin cytoskeleton and the kelch-domain-containing proteins Kel1p and Kel2p. While cells lacking Bud14p function fail to stabilize the pre-anaphase spindle at the mother-bud neck, overexpression of Bud14p is toxic and leads to elongated astral MTs and increased dynein-dependent sliding along the cell cortex. Bud14p physically interacts with the type-I phosphatase Glc7p, and localizes Glc7p to the bud cortex. Importantly, the formation of Bud14p-Glc7p complexes is necessary to regulate MT dynamics at the cortex. Taken together, our results suggest that Bud14p functions as a regulatory subunit of the Glc7p type-I phosphatase to stabilize MT interactions specifically at sites of polarized growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.