ArticleGenes and immunity2005
Characterization of the human CD5 endogenous retrovirus-E in B lymphocytes.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Interleukin-10 augments human endogenous retroviral E1B variant of cd5 in aged T cells.Blood research · 2025Article
- Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms.Frontiers in microbiology · 2019Article
- Immunophenotyping As a New Tool for Classification and Monitoring of Systemic Autoimmune Diseases.Clinical reviews in allergy & immunology · 2017Article
- EnHERV: Enrichment analysis of specific human endogenous retrovirus patterns and their neighboring genes.PloS one · 2017Article
- Review
- DNA methylation modulates HRES1/p28 expression in B cells from patients with Lupus.Autoimmunity · 2014Article
- Types of DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E and HERV-K in the neutrophils from systemic lupus erythematosus patients and healthy controls.Journal of human genetics · 2014Article
- The contribution of epigenetics in Sjögren's Syndrome.Frontiers in genetics · 2014Review
- Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents.International journal of clinical rheumatology · 2011Article
- Autoreactive B cells and epigenetics.Clinical reviews in allergy & immunology · 2010Review
- Article
- Characterization of rabbit CD5 isoforms.Molecular immunology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All T lymphocytes and some B lymphocytes express CD5. This coreceptor is encoded by one gene that consists of 11 exons. We have previously described a B cell-specific alternative exon 1, leading to the synthesis of a protein, devoid of leader peptide, and, therefore, retained in the cytoplasm. The novel exon 1 originates from a human endogenous retrovirus (HERV) at a time interval between the divergence of New World monkeys from Old World monkeys, and prior to the divergence of humans from Old World monkeys. Based on sequence similarity to gamma-retroviruses, it was categorized as class I: based on the specificity of its primer binding site, it was allotted to the subclass E, and based on its location within the cd5 gene, named HERV-E.CD5. Alternative transcripts were detected in lymphoid organs including fetal liver (not adult liver), more particularly in CD5-negative cell surface B-1b than in CD5-positive cell surface B-1a, and not at all in B-2 cells. By alignment of 5' long terminal repeats, HERV-E.CD5 was distinguished from similar proviruses. This could be central to the regulation of membrane expression of CD5 in human B lymphocytes, and, thereby, to the strength of the B-cell antigen receptor signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.