ReviewGenes and immunity2005
Current status of genetics research in inflammatory bowel disease.
Review in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- MYO9B gene polymorphisms are associated with the risk of inflammatory bowel diseases.Oncotarget · 2016Pooled it
- CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis.World journal of gastroenterology · 2015Pooled it
- MDR1 C3435T polymorphism and inflammatory bowel disease risk: a meta-analysis.Molecular biology reports · 2014Pooled it
- Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.PloS one · 2012Pooled it
- MiR-146a (rs2910164) Gene Polymorphism and Its Impact on Circulating MiR-146a Levels in Patients with Inflammatory Bowel Diseases.Inflammation · 2025Article
- Chronic Gastrointestinal Disorders and miRNA-Associated Disease: An Up-to-Date.International journal of molecular sciences · 2025Review
- Spermidine improves the antioxidant capacity and morphology of intestinal tissues and regulates intestinal microorganisms in Sichuan white geese.Frontiers in microbiology · 2023Article
- Budding Multi-matrix Technology-a Retrospective Approach, Deep Insights, and Future Perspectives.AAPS PharmSciTech · 2021Review
- Association of MYO9B gene polymorphisms with inflammatory bowel disease in Chinese Han population.World journal of gastroenterology · 2014Article
- Helicobacter pylori and Crohn's disease: a retrospective single-center study from China.World journal of gastroenterology · 2013Article
- Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor.Anti-cancer agents in medicinal chemistry · 2012Review
- Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.Archives of neurology · 2012Article
- Lipid storage myopathy.Current neurology and neuroscience reports · 2011Review
- SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.Annals of neurology · 2011Article
- Article
- Role of carnitine in disease.Nutrition & metabolism · 2010Article
- Phenotypic and genotypic characteristics of inflammatory bowel disease in French Canadians: comparison with a large North American repository.The American journal of gastroenterology · 2009Article
- OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.World journal of gastroenterology · 2008Article
- Dendritic cells and toll-like receptors 2 and 4 in the ileum of Crohn's disease patients.Digestive diseases and sciences · 2008Article
- Gene delivery to intestinal epithelial cells in vitro and in vivo with recombinant adeno-associated virus types 1, 2 and 5.Digestive diseases and sciences · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The research on genetic susceptibility of inflammatory bowel diseases (IBD) has been tremendous and over 10 chromosomal regions have been identified by genome-wide scanning. Further fine mapping as well as candidate gene studies have already led to the identification of a number of susceptibility genes including CARD15, DLG5, OCTN1 and 2, NOD1, HLA, and TLR4. The CARD15 gene is undoubtedly replicated most widely and most understood at present. CARD15 is involved in the recognition of bacterial peptidoglycan-derived muramyl dipeptide (MDP) and will stimulate secretion of antimicrobial peptides including alpha-defensins (also called cryptdins) to protect the host from invasion. Genetic research in IBD has advanced our understanding of the clinical heterogeneity of the disease and has started to tackle the complex interactions between genetic risk factors and environmental risk factors in IBD. Genes also interfere with the metabolization of drugs and may influence the clinical response and the drug-related toxicity. Interesting pharmacogenetic data with respect to steroids, azathioprine, and infliximab have been generated in IBD. Overall, it is anticipated that genetic markers in the future will be implemented in an integrated molecular diagnostic and prognostic approach of our patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.