ArticleMolecular and cellular biology2005
Differential phosphorylation controls Maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatus.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- eIF4E assembly intobioRxiv : the preprint server for biology · 2025Article
- Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics.eLife · 2025Article
- RNA in axons, dendrites, synapses and beyond.Frontiers in molecular neuroscience · 2024Review
- Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours.RNA biology · 2021Article
- The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.Scientific reports · 2017Article
- Translational Control of Germ Cell Decisions.Results and problems in cell differentiation · 2017Review
- Functional Integration of mRNA Translational Control Programs.Biomolecules · 2015Review
- Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity.BioMed research international · 2015Review
- TACC3 is a microtubule plus end-tracking protein that promotes axon elongation and also regulates microtubule plus end dynamics in multiple embryonic cell types.Molecular biology of the cell · 2014Article
- Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1.Genes & development · 2013Article
- A role of CPEB1 in the modulation of proliferation and neuronal maturation of rat primary neural progenitor cells.Neurochemical research · 2013Article
- Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics.Molecular and cellular biology · 2013Article
- Translational control in cellular and developmental processes.Nature reviews. Genetics · 2012Review
- Translational control in oocyte development.Cold Spring Harbor perspectives in biology · 2011Review
- Biochemical characterization of Pumilio1 and Pumilio2 in Xenopus oocytes.The Journal of biological chemistry · 2011Article
- The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.PloS one · 2011Article
- Translational control from head to tail.Current opinion in cell biology · 2009Review
- A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm.Journal of cell science · 2009Article
- CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation.Genes & development · 2008Article
- DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.Molecular cell · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Several cytoplasmic polyadenylation element (CPE)-containing mRNAs that are repressed in Xenopus oocytes become active during meiotic maturation. A group of factors that are anchored to the CPE are responsible for this repression and activation. Two of the most important are CPEB, which binds directly to the CPE, and Maskin, which associates with CPEB. In oocytes, Maskin also binds eukaryotic translation initiation factor 4E (eIF4E), an interaction that excludes eIF4G and prevents formation of the eIF4F initiation complex. When the oocytes are stimulated to reenter the meiotic divisions (maturation), CPEB promotes cytoplasmic polyadenylation. The newly elongated poly(A) tail becomes bound by poly(A) binding protein (PABP), which in turn binds eIF4G and helps it displace Maskin from eIF4E, thereby inducing translation. Here we show that Maskin undergoes several phosphorylation events during oocyte maturation, some of which are important for its dissociation from eIF4E and translational activation of CPE-containing mRNA. These sites are T58, S152, S311, S343, S453, and S638 and are phosphorylated by cdk1. Mutation of these sites to alanine alleviates the cdk1-induced dissociation of Maskin from eIF4E. Prior to maturation, Maskin is phosphorylated on S626 by protein kinase A. While this modification has no detectable effect on translation during oocyte maturation, it is critical for this protein to localize on the mitotic apparatus in somatic cells. These results show that Maskin activity and localization is controlled by differential phosphorylation.
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