ArticleMolecular and cellular biology2005
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
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- T cells in ARAP-deficient mice present defective T cell receptor signaling and reduced severity in an experimentally-induced autoimmune disease.Frontiers in immunology · 2025Article
- SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients.Immunologic research · 2024Article
- Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity.American journal of respiratory cell and molecular biology · 2022Article
- Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.Cell reports · 2022Article
- Corticotropin releasing hormone as an identifier of bronchiolitis obliterans syndrome.Scientific reports · 2022Article
- Runs of Homozygosity Uncover Potential Functional-Altering Mutation Associated With Body Weight and Length in Two Duroc Pig Lines.Frontiers in veterinary science · 2022Article
- Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.Human genetics · 2021Article
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- Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.Molecular and cellular biology · 2014Article
- Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis.Seminars in immunology · 2012Review
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- ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Regulation of lymphocyte development and activation by the LAT family of adapter proteins.Immunological reviews · 2009Review
- CD28 and CTLA-4 coreceptor expression and signal transduction.Immunological reviews · 2009Review
- CTLA-4 trafficking and surface expression.Trends in immunology · 2008Review
- Normal T-cell development and immune functions in TRIM-deficient mice.Molecular and cellular biology · 2006Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SIT is a transmembrane adapter protein that modulates signals emanating from the T-cell receptor (TCR). Here, we have used gene-targeted mice to assess the role of SIT for T-cell development and peripheral T-cell functions. SIT(-/-) double-positive thymocytes show an upregulation of the activation markers CD5 and CD69, suggesting that SIT negatively regulates TCR-mediated signals at the CD4(+) CD8(+) stage of thymic development. This assumption is further supported by the observation that in female H-Y TCR transgenic mice, positive selection is enhanced and even converted to negative selection. Similarly, mature peripheral T cells are hyperresponsive towards TCR-mediated stimuli and produce larger amounts of T-helper 1 (TH1) cytokines, and SIT-deficient mice show an increased susceptibility to develop experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. These results demonstrate that SIT is a critical negative regulator of TCR-mediated signaling and finely tunes the signals required for thymic selection and peripheral T-cell activation.
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