ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Complex regulation of spiral ganglion neuron firing patterns by neurotrophin-3.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Auditory hair cells and spiral ganglion neurons regenerate synapses with refined release properties in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Auditory Hair Cells and Spiral Ganglion Neurons Regenerate Synapses with Refined Release Properties In Vitro.bioRxiv : the preprint server for biology · 2023Article
- Isolating and Culturing Vestibular and Spiral Ganglion Somata from Neonatal Rodents for Patch-Clamp Recordings.Journal of visualized experiments : JoVE · 2023Article
- Axon-glia interactions in the ascending auditory system.Developmental neurobiology · 2021Review
- Similarities in the Biophysical Properties of Spiral-Ganglion and Vestibular-Ganglion Neurons in Neonatal Rats.Frontiers in neuroscience · 2021Article
- Functional Diversity of Neurotrophin Actions on the Oculomotor System.International journal of molecular sciences · 2016Review
- Treatment with Piribedil and Memantine Reduces Noise-Induced Loss of Inner Hair Cell Synaptic Ribbons.Scientific reports · 2016Article
- Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3.Scientific reports · 2016Article
- Sensitivity of spiral ganglion neurons to damage caused by mobile phone electromagnetic radiation will increase in lipopolysaccharide-induced inflammation in vitro model.Journal of neuroinflammation · 2015Article
- Unmasking of spiral ganglion neuron firing dynamics by membrane potential and neurotrophin-3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neural progenitor cell implants in the lesioned medial longitudinal fascicle of adult cats regulate synaptic composition and firing properties of abducens internuclear neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Heterogeneous intrinsic excitability of murine spiral ganglion neurons is determined by Kv1 and HCN channels.Neuroscience · 2014Article
- Characterization of neuronal cell death in the spiral ganglia of a mouse model of endolymphatic hydrops.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2013Article
- BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells.Stem cell research · 2013Article
- Challenges for stem cells to functionally repair the damaged auditory nerve.Expert opinion on biological therapy · 2013Review
- The use of neurotrophin therapy in the inner ear to augment cochlear implantation outcomes.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development.Neural development · 2011Article
- The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti.Hearing research · 2011Review
- Synaptic proteins are tonotopically graded in postnatal and adult type I and type II spiral ganglion neurons.The Journal of comparative neurology · 2011Article
- Complex primary afferents: What the distribution of electrophysiologically-relevant phenotypes within the spiral ganglion tells us about peripheral neural coding.Hearing research · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Auditory information is conveyed into the CNS via the spiral ganglion neurons, cells that possess distinctive electrophysiological properties that vary according to their cochlear innervation. Neurons from the base of the cochlea fire action potentials with shorter latencies and durations with more rapid accommodation than apical neurons (Adamson et al., 2002b). Interestingly, these features are altered by exposure to brain-derived neurotrophic factor and neurotrophin-3 (NT-3), suggesting that the electrophysiological diversity is not preprogrammed into the neurons but instead results from extrinsic regulation. In support of this, gradients of neurotrophins exist in the cochlea that could account for the apex- base differences in firing. To understand the determinants of spiral ganglion function, we characterized the NT-3 concentration dependence and mode of action on spiral ganglion neurons. Whole-cell current-clamp recordings were made from mouse basal spiral ganglion neurons (postnatal day 5) exposed to different concentrations of NT-3 for 3 d in vitro. Measurements of accommodation, latency, onset time course, and action potential latency revealed a nonmonotonic dependence on NT-3 concentration, with a peak effect occurring at 10 ng/ml. Addition of NT-3 at different time points showed that neurotrophin exposure altered the firing features of existing neurons rather than supporting differential survival. These experiments establish that the electrophysiological phenotype of spiral ganglion neurons depends critically on the precise concentration of NT-3 and that the functional organization of this component of the peripheral auditory system results from a complex interplay between multiple kinds of neurotrophins and their cognate receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.