ArticleMolecular biology of the cell2005
A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Fusarium oxysporum f. sp.mBio · 2023Article
- Synthetic negative genome screen of the GPN-loop GTPase NPA3 in Saccharomyces cerevisiae.Current genetics · 2022Article
- Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.PLoS genetics · 2021Article
- Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions.Cellular and molecular life sciences : CMLS · 2021Review
- Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity.Nucleic acids research · 2019Article
- Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins.Nucleic acids research · 2019Article
- TaARPC3, Contributes to Wheat Resistance against the Stripe Rust Fungus.Frontiers in plant science · 2017Article
- Autophagy and epithelial-mesenchymal transition: an intricate interplay in cancer.Cell death & disease · 2016Review
- Heterodimeric capping protein from Arabidopsis is a membrane-associated, actin-binding protein.Plant physiology · 2014Article
- Inheritance of the fittest mitochondria in yeast.Trends in cell biology · 2014Review
- The actin-related Protein2/3 complex regulates mitochondrial-associated calcium signaling during salt stress in Arabidopsis.The Plant cell · 2013Article
- The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.The Journal of cell biology · 2011Article
- Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis.Yeast (Chichester, England) · 2011Article
- Pumilio Puf domain RNA-binding proteins in Arabidopsis.Plant signaling & behavior · 2011Review
- The association of the Arabidopsis actin-related protein2/3 complex with cell membranes is linked to its assembly status but not its activation.Plant physiology · 2009Article
- Pushing for answers: is myosin V directly involved in moving mitochondria?The Journal of cell biology · 2008Article
- Puf1p acts in combination with other yeast Puf proteins to control mRNA stability.RNA (New York, N.Y.) · 2008Article
- Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast.The Journal of cell biology · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although the Arp2/3 complex localizes to the leading edge of motile cells, endocytic structures, and mitochondria in budding yeast, the mechanism for targeting the Arp2/3 complex to different regions in the cell is not well understood. We find that Jsn1p, a member of the PUF family of proteins, facilitates association of Arp2/3 complex to yeast mitochondria. Jsn1p localizes to punctate structures that align along mitochondria, cofractionates with a mitochondrial marker protein during subcellular fractionation, and is both protease sensitive and carbonate extractable in isolated mitochondria. Thus, Jsn1p is a peripheral membrane protein that is associated with the outer leaflet of the mitochondrial outer membrane. Jsn1p colocalized and coimmunoprecipitated with mitochondria-associated Arc18p-GFP, and purified Arp2/3 complex bound to isolated TAP-tagged Jsn1p. Moreover, deletion of JSN1 reduces the amount of Arc18p-GFP that colocalizes and is recovered with mitochondria twofold, and jsn1Delta cells exhibited defects in mitochondrial morphology and motility similar to those observed in Arp2/3 complex mutants. Thus, Jsn1p has physical interactions with mitochondria-associated Arp2/3 complex and contributes to physical and functional association of the Arp2/3 complex with mitochondria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.