ArticleBritish journal of cancer2005
Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Distribution of high- and low-risk human papillomavirus genotypes and their prophylactic vaccination coverage among West African women: systematic review.Journal of the Egyptian National Cancer Institute · 2023Pooled it
- Prevalence and Genotype Distribution of High-Risk Human Papillomavirus Infection Among Sub-Saharan African Women: A Systematic Review and Meta-Analysis.Frontiers in public health · 2022Pooled it
- Pooled it
- 20-years of population-based cancer registration in hepatitis B and liver cancer prevention in the Gambia, West Africa.PloS one · 2013Trial
- Article
- Article
- Human papillomavirus type-specific distribution in cervical intraepithelial neoplasia and cancer in The Gambia prior to HPV immunization programme: a baseline for monitoring the quadrivalent vaccine.Infectious agents and cancer · 2024Article
- Risk Factors for Cervical Cancer in Ghana.Cancer reports (Hoboken, N.J.) · 2024Article
- The spectrum of opportunistic infections and malignancies among women on antiretroviral therapy in Ethiopia.Emerging microbes & infections · 2023Article
- Self-Collected Specimens Revealed a Higher Vaccine- and Non-Vaccine-Type Human Papillomavirus Prevalences in a Cross-Sectional Study in Akuse.Advances in preventive medicine · 2020Article
- Differences in age-specific HPV prevalence between self-collected and health personnel collected specimen in a cross-sectional study in Ghana.Infectious agents and cancer · 2017Article
- Human papillomavirus infection in Rwanda at the moment of implementation of a national HPV vaccination programme.BMC infectious diseases · 2016Article
- Age-specific prevalence of human papilloma virus infection among Nigerian women.BMC public health · 2014Article
- The burden of human papillomavirus infections and related diseases in sub-saharan Africa.Vaccine · 2013Review
- Plasma cytokine levels and human papillomavirus infection at the cervix in rural Nigerian women.Cytokine · 2013Article
- The age-specific prevalence of human papillomavirus and risk of cytologic abnormalities in rural Nigeria: implications for screen-and-treat strategies.International journal of cancer · 2012Article
- Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women.Infectious agents and cancer · 2011Article
- A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria.Infectious agents and cancer · 2011Article
- Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study.BMC infectious diseases · 2011Article
- Human papillomavirus infection in women with and without cervical cancer in Ibadan, Nigeria.Infectious agents and cancer · 2010Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of effective strategies against cervical cancer in Africa requires accurate type specific data on human papillomavirus (HPV) prevalence, including determination of DNA sequences in order to maximise local vaccine efficacy. We have investigated cervical HPV infection and squamous intraepithelial lesions (SIL) in an unselected cohort of 1061 women in a rural Gambian community. Squamous intraepithelial lesions was diagnosed using cytology and histology, HPV was typed by PCR-ELISA of DNA extracts, which were also DNA sequenced. The prevalence of cervical HPV infection was 13% and SIL were observed in 7% of subjects. Human papillomavirus-16 was most prevalent and most strongly associated with SIL. Also common were HPV-18, -33, -58 and, notably, -35. Human papillomavirus DNA sequencing revealed HPV-16 samples to be exclusively African type 1 (Af1). Subjects of the Wolof ethnic group had a lower prevalence of HPV infection while subjects aged 25-44 years had a higher prevalence of cervical precancer than older or younger subjects. This first report of HPV prevalence in an unselected, unscreened rural population confirms high rates of SIL and HPV infection in West Africa. This study has implications for the vaccination of Gambian and other African populations in the prevention of cervical cancer.
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Registered trials
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