ReviewImmunologic research2005
Lymphocyte antigen receptor gene assembly: multiple layers of regulation.
Review in Immunologic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Immunology · 2013Review
- Review
- Unstable DNA repair genes shaped by their own sequence modifying phenotypes.Journal of molecular evolution · 2010Article
- Role of the translocation partner in protection against AID-dependent chromosomal translocations.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphocyte antigen receptor genes are assembled through the cutting and joining of segments of DNA in developing lymphocytes. The basic features of the biochemical steps of this assembly process, referred to as the V(D)J recombination, are similar for the assembly of all lymphocyte antigen receptor genes, yet this assembly is precisely regulated in several important contexts during lymphocyte development. It has long been appreciated that this occurs through modulation of accessibility of antigen receptor loci to the enzymatic complex that assembles antigen receptor genes. However, recent studies have suggested that some regulatory constraints may be enforced at the level of the V(D)J recombination reaction itself. This review focuses on recent advances in the understanding of the regulation of antigen receptor gene assembly, with particular attention paid to the assembly of T-cell receptor beta-chain genes during T-cell development.
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Identifiers
16106077What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.