ReviewImmunologic research2005
Signals from dying cells: tolerance induction by the dendritic cell.
Review in Immunologic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Resistance to the proapoptotic effects of interferon-gamma on melanoma cells used in patient-specific dendritic cell immunotherapy is associated with improved overall survival.Cancer immunology, immunotherapy : CII · 2011Trial
- Selective depletion of CD11cEuropean journal of immunology · 2016Article
- Breaking T cell tolerance to beta cell antigens by merocytic dendritic cells.Cellular and molecular life sciences : CMLS · 2011Review
- Armed response: how dying cells influence T-cell functions.Immunological reviews · 2011Review
- Article
- Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo.Clinical and experimental immunology · 2011Article
- Exposure to apoptotic activated CD4+ T cells induces maturation and APOBEC3G-mediated inhibition of HIV-1 infection in dendritic cells.PloS one · 2011Article
- Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen.Clinical immunology (Orlando, Fla.) · 2010Article
- Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches.Cancer immunology, immunotherapy : CII · 2009Article
- Separating graft-versus-leukemia from graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.Immunotherapy · 2009Review
- CD4+CD25+ T regulatory cells induced by LPS-activated bone marrow dendritic cells suppress experimental autoimmune uveoretinitis in vivo.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Uncontrolled immune responses are central to the pathogenesis of sustained viral infection, tumor growth, autoimmune diseases, and organ rejection. Dendritic cells (DCs) are critical to determining the outcome of immune responses by directing the function of T-cells. When DCs encounter antigen together with maturation signals immunity results; however, when they encounter apoptotic cells immune tolerance can be induced. It is thought that this is a mechanism to help prevent responses to self antigens because apoptotic cells can enter antigen-processing pathways. Our interest is the mechanisms by which DCs induce tolerance to the antigens associated with apoptotic cells. Here, we examine evidence showing a pivotal role for interleukin-10 (IL-10) in regulating the response of DCs to apoptotic cells. We show that although tolerogenic DCs are CD11c+ and CD8alpha+, the important DCs reside in a subpopulation of these cells that also express IL-10R. Current studies are designed to isolate and characterize this extremely small, but potent, subpopulation of tolerance-inducing DCs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.