Evidence map›Paper›PMID 16106059›Full record

ReviewImmunologic research2005

Developmental relationship between hematopoietic and endothelial cells.

Jesse J Lugus, Changwon Park, Kyunghee Choi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Receptor tyrosine kinase-mediated angiogenesis.Cold Spring Harbor perspectives in biology · 2013
    Review
  3. Article
  4. Article
  5. Article
  6. Vascular endothelium: the battlefield of dengue viruses.FEMS immunology and medical microbiology · 2008
    Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jesse J LugusDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Changwon Park
Kyunghee Choi
Washington University in St. Louis · US

Funding

Hemangioglast Development and RegulationR01HL055337 · NHLBI · WASHINGTON UNIVERSITY · PI CHOI, KYUNGHEE · 2001 to 2024
$9.1M
HEMATOPOIETIC COMMITMENT: MOLECULAR MECHANISMSR01HL063736 · NHLBI · WASHINGTON UNIVERSITY · PI CHOI, KYUNGHEE · 2000 to 2016
$5.6M
NHLBI NIH HHS R01 HL55337NHLBI NIH HHS R01 HL63736
6 · The paper itself

Abstract

Blood (hematopoietic cells) and blood vessels (endothelial cells) develop from mesoderm via a transitional progenitor known as the hemangioblast. Flk-1, a receptor tyrosine kinase, and Scl, a basic helix-loop-helix transcription factor, are two critical molecules functioning in this process. Recent studies have shown that Flk-1 expressing mesoderm contributes to the circulatory system, including hematopoietic, endothelial, smooth muscle, skeletal muscle, and cardiac muscle cells. Our studies suggest that hemangioblast specification within Flk-1 expressing mesoderm is regulated by Scl expression. Herein, we review studies that have utilized transgenic mouse models as well as an in vitro model of embryonic stem cell differentiation, both of which have greatly contributed to the current understanding of the cellular and molecular pathways regulating hemangioblast development and differentiation.

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationColony-Forming Units AssayEndothelium, VascularHematopoiesisHematopoietic Stem CellsIn Vitro TechniquesMiceMice, TransgenicProto-Oncogene ProteinsSignal TransductionT-Cell Acute Lymphocytic Leukemia Protein 1Transcription, GeneticVascular Endothelial Growth Factor Receptor-2Yolk SacBasic Helix-Loop-Helix ProteinsProto-Oncogene ProteinsTal1 protein, mouseT-Cell Acute Lymphocytic Leukemia Protein 1Vascular Endothelial Growth Factor Receptor-2

Identifiers

PMID16106059
OpenAlexW2021198453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.