ReviewImmunologic research2005
T-cell stimulation and regulation: with complements from CD46.
Review in Immunologic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Exploring program-cell death patterns to predict prognosis and sensitivity of cervical cancer immunotherapy via multi-omics analysis and clinical samples.Discover oncology · 2025Article
- HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance.Frontiers in immunology · 2024Article
- The complement regulatory protein CD46 serves as a novel biomarker for cervical cancer diagnosis and prognosis evaluation.Frontiers in immunology · 2024Article
- The Screening of Therapeutic Peptides for Anti-Inflammation through Phage Display Technology.International journal of molecular sciences · 2022Review
- A Novel Prognostic Risk Model for Cervical Cancer Based on Immune Checkpoint HLA-G-Driven Differentially Expressed Genes.Frontiers in immunology · 2022Article
- Aspects of the Complement System in New Era of Xenotransplantation.Frontiers in immunology · 2022Review
- The "ins and outs" of complement-driven immune responses.Immunological reviews · 2016Review
- Inhibition of CXCL10 release by monomeric C3bi and C4b.Clinical and experimental immunology · 2012Article
- CD46 in innate and adaptive immunity: an update.Clinical and experimental immunology · 2011Review
- A novel role for CD46 in wound repair.Frontiers in immunology · 2011Article
- The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts.Journal of lipids · 2011Article
- Measles virus-induced immunosuppression: from effectors to mechanisms.Medical microbiology and immunology · 2010Review
- Role and mechanism of action of complement in regulating T cell immunity.Molecular immunology · 2010Review
- CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection.Infection and immunity · 2009Article
- CD46-induced human Treg enhance B-cell responses.European journal of immunology · 2009Article
- Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis.Immunogenetics · 2009Article
- T regulatory type 1 cells in squamous cell carcinoma of the head and neck: mechanisms of suppression and expansion in advanced disease.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Epistasis between the MHC and the RCA alpha block in primary Sjögren syndrome.Annals of the rheumatic diseases · 2008Article
- Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3.The EMBO journal · 2008Article
- Downregulation of human CD46 by adenovirus serotype 35 vectors.Gene therapy · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Crosslinking of CD46 and CD3 on naïve human CD4+ T-lymphocytes induces interleukin-10 secretion and granzyme B expression. These highly proliferative T-regulatory type 1-like T-regulatory T-cells (Tregs) can suppress an immune response. We propose that this process is important in the prevention of chronic inflammation such as at epithelial borders and in deactivation of a successful immune response. Relative to the latter, once a complement-fixing polyclonal antibody response has been mounted, in most cases, the pathogen will be rapidly destroyed. At this time, the C3b/C4b-bearing immune complexes could initiate the deactivation arm of an immune response by shutting down immunocompetent cells through CD46-generated T-cells. Herein, we review this pathway for the induction of Tregs, focusing on a role for the complement system and especially signaling through CD46 on human T-cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.