Trial reportAIDS (London, England)2005
Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine.
Trial report in AIDS (London, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis.AIDS (London, England) · 2012Pooled it
- Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.The Cochrane database of systematic reviews · 2011Pooled it
- Dynamic Changes in Breast Milk Microbiome in the Early Postpartum Period of Kenyan Women Living with HIV Are Influenced by Antibiotics but Not Antiretrovirals.Microbiology spectrum · 2022Trial
- Infant feeding practices were not associated with breast milk HIV-1 RNA levels in a randomized clinical trial in Botswana.AIDS and behavior · 2012Trial
- Temporal reduction of HIV type 1 viral load in breast milk by single-dose nevirapine during prevention of MTCT.AIDS research and human retroviruses · 2009Trial
- Predictors of early and late mother-to-child transmission of HIV in a breastfeeding population: HIV Network for Prevention Trials 012 experience, Kampala, Uganda.Journal of acquired immune deficiency syndromes (1999) · 2009Trial
- Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana.The Journal of infectious diseases · 2009Trial
- HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission.AIDS (London, England) · 2008Trial
- Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feeding.Journal of acquired immune deficiency syndromes (1999) · 2008Trial
- Highly active antiretroviral therapy versus zidovudine/nevirapine effects on early breast milk HIV type-1 Rna: a phase II randomized clinical trial.Antiviral therapy · 2008Trial
- Independent effects of nevirapine prophylaxis and HIV-1 RNA suppression in breast milk on early perinatal HIV-1 transmission.Journal of acquired immune deficiency syndromes (1999) · 2007Trial
- Post-weaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume.AIDS (London, England) · 2006Trial
- Maternal plasma and breastmilk viral loads are associated with HIV-1-specific cellular immune responses among HIV-1-exposed, uninfected infants in Kenya.Clinical and experimental immunology · 2015Article
- The role of cell-associated virus in mother-to-child HIV transmission.The Journal of infectious diseases · 2014Review
- Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding.PloS one · 2012Article
- Survival and health benefits of breastfeeding versus artificial feeding in infants of HIV-infected women: developing versus developed world.Clinics in perinatology · 2010Review
- HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission.Journal of the International AIDS Society · 2009Article
- Infant feeding and prevention of mother-to-child transmission of HIV-1.Current opinion in HIV and AIDS · 2008Article
- African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine.AIDS (London, England) · 2007Article
- Risk of breast, ovary, and uterine corpus cancers among 85,268 women with AIDS.British journal of cancer · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo compare the effect of perinatal regimens of short-course nevirapine (HIVNET 012) and zidovudine [Thai-Centers for Disease Control and Prevention (CDC) regimen] on breast milk viral shedding and perinatal transmission during the first 6 weeks postpartum in a randomized clinical trial.
designRandomized clinical trial.
methodsPregnant HIV-1 seropositive women in Nairobi, Kenya who planned to breastfeed were randomized to HIVNET 012 or Thai-CDC regimens. Two to four breast milk samples were collected each week between delivery and 6 weeks postpartum. Breast milk HIV-1 RNA was quantified using the Gen-Probe TMA assay. Infants were tested for HIV-1 DNA at birth and 6 weeks.
resultsFrom March to October 2003, 76 women were enrolled and 795 breast milk samples were collected from 60 women who were randomized and followed after delivery. Between 3 and 21 days postpartum, nevirapine was associated with significantly greater suppression of breast milk log10 HIV-1 RNA: days 3 to 7 (1.98 versus 2.42, P = 0.1); days 8 to 14 (1.78 versus 2.48, P = 0.005); days 15 to 21 (1.90 versus 2.97, P = 0.003). At 6 weeks, the HIV-1 perinatal transmission rate was significantly lower among those who took nevirapine than zidovudine (6.8% versus 30.3%, P = 0.02).
conclusionsCompared to a peripartum zidovudine regimen, nevirapine was significantly more likely to decrease HIV-1 RNA in breast milk during the first week and through the third week postpartum following single-dose administration, and corresponded with decreased transmission risk at 6 weeks. Sustained breast milk HIV-1 suppression may contribute to the ability of nevirapine to decrease perinatal transmission of HIV-1.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.