ArticleProceedings of the National Academy of Sciences of the United States of America2005
Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Association of Macrophage Migration Inhibitory Factor-794 CATT Microsatellite Polymorphism With Tuberculosis Risk: A Systematic Review and Meta-Analysis.Pulmonary medicine · 2026Pooled it
- The 2SP Site Mutation in the Bovine Natural Resistance-Associated Macrophage 1 Promoter Exhibits Antituberculosis Potential.International journal of molecular sciences · 2025Article
- Effect of breastfeeding on children's health and its relationship to NRAMP1 expression: A cross-sectional study.Annals of medicine and surgery (2012) · 2021Article
- Macrophage migration inhibitory factor - 794 CATTInfection · 2021Article
- Genetics and evolution of tuberculosis pathogenesis: New perspectives and approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- The monogenic basis of human tuberculosis.Human genetics · 2020Review
- Macrophage migration inhibitory factor -173 G>C single nucleotide polymorphism and its association with active pulmonary tuberculosis.PloS one · 2020Article
- Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives.The Lancet. Infectious diseases · 2018Review
- Human Genomics ofCurrent genetic medicine reports · 2017Article
- Article
- A genome-wide association study of pulmonary tuberculosis in Morocco.Human genetics · 2016Article
- Tuberculosis in Newborns: The Lessons of the "Lübeck Disaster" (1929-1933).PLoS pathogens · 2016Review
- Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus.Pathogens (Basel, Switzerland) · 2015Review
- Co-evolution of Mycobacterium tuberculosis and Homo sapiens.Immunological reviews · 2015Review
- Association of the FCN2 Gene Single Nucleotide Polymorphisms with Susceptibility to Pulmonary Tuberculosis.PloS one · 2015Article
- Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease.PloS one · 2015Article
- Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3.PLoS neglected tropical diseases · 2014Article
- Human genetics of tuberculosis: a long and winding road.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.American journal of human genetics · 2013Article
- Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Relatively little is known about the human genetics of susceptibility to common diseases caused by bacterial pathogens. Tuberculosis, caused by Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. So far, genetic studies of tuberculosis susceptibility have largely been focused on adult patients despite the fact that tuberculosis is highly prevalent among children. To study the host genetic component of pediatric tuberculosis susceptibility, we enrolled 184 ethnically diverse families from the Greater Houston area with at least one child affected by pediatric tuberculosis disease. Using a family-based control design, we found allelic variants of the natural resistance-associated macrophage protein gene 1 (NRAMP1) (alias SLC11A1) significantly associated with tuberculosis disease in this pediatric patient population [P = 0.01; odds ratio = 1.75 (95% confidence interval, 1.10-2.77)]. The association of NRAMP1 with pediatric tuberculosis disease was significantly heterogeneous (P = 0.01) between simplex [P <0.0008; odds ratio = 3.13 (1.54-6.25)] and multiplex families (P = 1), suggesting an interplay between mechanisms of genetic control and exposure intensities. In striking contrast to previous studies in the adult population, we observed that the common alleles of NRAMP1 polymorphisms were risk factors for pediatric tuberculosis disease. To explain the different direction of allelic association between adult and pediatric disease, we hypothesize that NRAMP1 influences the speed of progression from infection to tuberculosis disease.
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