ArticleThe Journal of general physiology2005
The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.
Article in The Journal of general physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Structural mapping of patient-associated KCNMA1 gene variants.Biophysical journal · 2024Article
- An allosteric modulator activates BK channels by perturbing coupling between CaNature communications · 2022Article
- BK Channel Gating Mechanisms: Progresses Toward a Better Understanding of Variants Linked Neurological Diseases.Frontiers in physiology · 2021Review
- Coupling of CaProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Effects of Single Nucleotide Polymorphisms in HumanFrontiers in molecular neuroscience · 2019Article
- Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.The Journal of general physiology · 2017Review
- Pore size matters for potassium channel conductance.The Journal of general physiology · 2016Review
- Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels.PloS one · 2016Article
- BK channels: multiple sensors, one activation gate.Frontiers in physiology · 2015Review
- Single-channel kinetics of BK (Slo1) channels.Frontiers in physiology · 2014Review
- The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.Neuron · 2010Article
- Allosteric mechanism of Ca2+ activation and H+-inhibited gating of the MthK K+ channel.The Journal of general physiology · 2010Article
- Regulation of synaptic transmission by presynaptic CaMKII and BK channels.Molecular neurobiology · 2008Review
- A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.Biophysical journal · 2008Article
- Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Presynaptic Ca2+/calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels.Neuroscience · 2007Article
- Gating and conductance changes in BK(Ca) channels in bilayers are reciprocal.The Journal of membrane biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Large conductance, voltage- and Ca2+-activated K+ (BK(Ca)) channels regulate blood vessel tone, synaptic transmission, and hearing owing to dual activation by membrane depolarization and intracellular Ca2+. Similar to an archeon Ca2+-activated K+ channel, MthK, each of four alpha subunits of BK(Ca) may contain two cytosolic RCK domains and eight of which may form a gating ring. The structure of the MthK channel suggests that the RCK domains reorient with one another upon Ca2+ binding to change the gating ring conformation and open the activation gate. Here we report that the conformational changes of the NH2 terminus of RCK1 (AC region) modulate BK(Ca) gating. Such modulation depends on Ca2+ occupancy and activation states, but is not directly related to the Ca2+ binding sites. These results demonstrate that AC region is important in the allosteric coupling between Ca2+ binding and channel opening. Thus, the conformational changes of the AC region within each RCK domain is likely to be an important step in addition to the reorientation of RCK domains leading to the opening of the BK(Ca) activation gate. Our observations are consistent with a mechanism for Ca2+-dependent activation of BK(Ca) channels such that the AC region inhibits channel activation when the channel is at the closed state in the absence of Ca2+; Ca2+ binding and depolarization relieve this inhibition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.