ArticleJournal of virology2005
Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- HIV-1 Vpr Functions in Primary CD4Viruses · 2024Review
- Relationship between Measures of HIV Reactivation and Decline of the Latent Reservoir under Latency-Reversing Agents.Journal of virology · 2017Article
- Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway.Journal of virology · 2016Article
- Article
- Intracellular dynamics of HIV infection.Journal of virology · 2014Article
- Mining differential top-k co-expression patterns from time course comparative gene expression datasets.BMC bioinformatics · 2013Article
- An efficient method for mining cross-timepoint gene regulation sequential patterns from time course gene expression datasets.BMC bioinformatics · 2013Article
- Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells.Journal of neuroinflammation · 2012Article
- Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes.The Journal of biological chemistry · 2011Article
- Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response.Immunologic research · 2010Review
- Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation.Immunology · 2009Article
- Article
- Yeast genetic analysis reveals the involvement of chromatin reassembly factors in repressing HIV-1 basal transcription.PLoS genetics · 2009Article
- Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells.Virology journal · 2008Article
- Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor.Retrovirology · 2008Article
- Dynamical pathway analysis.BMC systems biology · 2008Article
- G2/M cell cycle arrest in the life cycle of viruses.Virology · 2007Review
- Host factors that control long terminal repeat retrotransposons in Saccharomyces cerevisiae: implications for regulation of mammalian retroviruses.Eukaryotic cell · 2007Review
- The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity.Journal of virology · 2007Article
- Chlamydia trachomatis infection induces cleavage of the mitotic cyclin B1.Infection and immunity · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The human immunodeficiency virus type 1 (HIV-1) Vpr protein has important functions in advancing HIV pathogenesis via several effects on the host cell. Vpr mediates nuclear import of the preintegration complex, induces host cell apoptosis, and inhibits cell cycle progression at G(2), which increases HIV gene expression. Some of Vpr's activities have been well described, but some functions, such as cell cycle arrest, are not yet completely characterized, although components of the ATR DNA damage repair pathway and the Cdc25C and Cdc2 cell cycle control mechanisms clearly play important roles. We investigated the mechanisms underlying Vpr-mediated cell cycle arrest by examining global cellular gene expression profiles in cell lines that inducibly express wild-type and mutant Vpr proteins. We found that Vpr expression is associated with the down-regulation of genes in the MEK2-ERK pathway and with decreased phosphorylation of the MEK2 effector protein ERK. Exogenous provision of excess MEK2 reverses the cell cycle arrest associated with Vpr, confirming the involvement of the MEK2-ERK pathway in Vpr-mediated cell cycle arrest. Vpr therefore appears to arrest the cell cycle at G(2)/M through two different mechanisms, the ATR mechanism and a newly described MEK2 mechanism. This redundancy suggests that Vpr-mediated cell cycle arrest is important for HIV replication and pathogenesis. Our findings additionally reinforce the idea that HIV can optimize the host cell environment for viral replication.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.