ArticleJournal of virology2005
Down-regulation of p53 by double-stranded RNA modulates the antiviral response.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche.Nature communications · 2025Article
- Adaptive homeostasis and the p53 isoform network.EMBO reports · 2021Review
- C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.Human molecular genetics · 2021Article
- P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.International journal of molecular sciences · 2020Review
- Article
- Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms.PLoS pathogens · 2019Article
- PKR: A Kinase to Remember.Frontiers in molecular neuroscience · 2018Review
- Article
- Interplay between the virus and the ubiquitin-proteasome system: molecular mechanism of viral pathogenesis.Current opinion in virology · 2016Review
- PI3K/Akt/p53 pathway inhibits reovirus infection.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Transcriptional correlates of disease outcome in anticoagulant-treated non-human primates infected with ebolavirus.PLoS neglected tropical diseases · 2014Article
- Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells.Molecular and cellular biology · 2012Article
- Respiratory syncytial virus matrix protein induces lung epithelial cell cycle arrest through a p53 dependent pathway.PloS one · 2012Article
- Ethanol Extract from Ampelopsis sinica Root Exerts Anti-Hepatitis B Virus Activity via Inhibition of p53 Pathway In Vitro.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Proteasome activator REGgamma enhances coxsackieviral infection by facilitating p53 degradation.Journal of virology · 2010Article
- Viral apoptosis is induced by IRF-3-mediated activation of Bax.The EMBO journal · 2010Article
- Dual Role of p53 in Innate Antiviral Immunity.Viruses · 2010Article
- Article
- PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease.Journal of cellular and molecular medicine · 2009Review
- PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
p53 has been well characterized as a tumor suppressor gene, but its role in antiviral defense remains unclear. A recent report has demonstrated that p53 can be induced by interferons and is activated after vesicular stomatitis virus (VSV) infection. We observed that different nononcogenic viruses, including encephalomyocarditis virus (EMCV) and human parainfluenza virus type 3 (HPIV3), induced down-regulation of p53 in infected cells. Double-stranded RNA (dsRNA) and a mutant vaccinia virus lacking the dsRNA binding protein E3L can also induce this effect, indicating that dsRNA formed during viral infection is likely the trigger for down-regulation of p53. The mechanism of down-regulation of p53 by dsRNA relies on translation inhibition mediated by the PKR and RNase L pathways. In the absence of p53, the replication of both EMCV and HPIV3 was retarded, whereas, conversely, VSV replication was enhanced. Cell cycle analysis indicated that wild-type (WT) but not p53 knockout (KO) fibroblasts undergo an early-G(1) arrest following dsRNA treatment. Moreover, in WT cells the onset of dsRNA-induced apoptosis begins after p53 levels are down-regulated, whereas p53 KO cells, which lack the early-G(1) arrest, rapidly undergo apoptosis. Hence, our data suggest that the down-regulation of p53 facilitates apoptosis, thereby limiting viral replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.