ArticleJournal of virology2005
Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 93 citations in OpenAlex.
- Redefining the immune landscape of hepatitis A virus infection.Experimental & molecular medicine · 2025Review
- Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation.Cell communication and signaling : CCS · 2024Article
- Structural Investigations of Interactions between the Influenza a Virus NS1 and Host Cellular Proteins.Viruses · 2023Review
- Harnessing Natural Killer Cell-Mediated Innate Immune Responses for Cancer Treatment: Advances and Challenges.Exploratory research and hypothesis in medicine · 2022Article
- Prolonged Gut Dysbiosis and Fecal Excretion of Hepatitis A Virus in Patients Infected with Human Immunodeficiency Virus.Viruses · 2021Observational
- Human Norovirus NTPase Antagonizes Interferon-β Production by Interacting With IkB Kinase ε.Frontiers in microbiology · 2021Article
- Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion.Frontiers in microbiology · 2021Review
- Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections.Reviews in medical virology · 2019Review
- Innate Immunity to Enteric Hepatitis Viruses.Cold Spring Harbor perspectives in medicine · 2019Review
- IRF4 and IRGs Delineate Clinically Relevant Gene Expression Signatures in Systemic Lupus Erythematosus and Rheumatoid Arthritis.Frontiers in immunology · 2018Article
- Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus.Frontiers in microbiology · 2018Review
- The NS1 protein of H5N6 feline influenza virus inhibits feline beta interferon response by preventing NF-κB and IRF3 activation.Developmental and comparative immunology · 2017Article
- CXCL10 is produced in hepatitis A virus-infected cells in an IRF3-dependent but IFN-independent manner.Scientific reports · 2017Article
- In vitro antiviral effect of germacrone on feline calicivirus.Archives of virology · 2016Article
- Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.Journal of virology · 2015Article
- Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway.Virology journal · 2015Article
- Article
- Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes.Frontiers in microbiology · 2015Article
- Regulation of RIG-I-like receptor signaling by host and viral proteins.Cytokine & growth factor reviews · 2014Review
- Molecular biology and inhibitors of hepatitis A virus.Medicinal research reviews · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of double-stranded RNA (dsRNA)-induced beta interferon (IFN-beta) gene expression. In this report, we show that this is due to an interaction of HAV with the intracellular dsRNA-induced retinoic acid-inducible gene I (RIG-I)-mediated signaling pathway upstream of the kinases responsible for interferon regulatory factor 3 (IRF-3) phosphorylation (TBK1 and IKKepsilon). In consequence, IRF-3 is not activated for nuclear translocation and gene induction. In addition, we found that HAV reduces TRIF (TIR domain-containing adaptor inducing IFN-beta)-mediated IRF-3 activation, which is part of the Toll-like receptor 3 signaling pathway. As IRF-3 is necessary for IFN-beta transcription, inhibition of this factor results in efficient suppression of IFN-beta synthesis. This ability of HAV seems to be of considerable importance for HAV replication, as HAV is not resistant to IFN-beta, and it may allow the virus to establish infection and preserve the sites of virus production in later stages of the infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.